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Direct Binding to NLRP3 Pyrin Domain as a Novel Strategy to Prevent NLRP3-Driven Inflammation and Gouty Arthritis.
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2020-03-05 , DOI: 10.1002/art.41245 Gabsik Yang 1 , Hye E Lee 1 , Su-Jin Moon 2 , Kyung M Ko 3 , Jung H Koh 3 , Jin K Seok 1 , Jun-Ki Min 3 , Tae-Hwe Heo 1 , Han C Kang 1 , Yong-Yeon Cho 1 , Hye S Lee 1 , Katherine A Fitzgerald 4 , Joo Y Lee 1
Arthritis & Rheumatology ( IF 11.4 ) Pub Date : 2020-03-05 , DOI: 10.1002/art.41245 Gabsik Yang 1 , Hye E Lee 1 , Su-Jin Moon 2 , Kyung M Ko 3 , Jung H Koh 3 , Jin K Seok 1 , Jun-Ki Min 3 , Tae-Hwe Heo 1 , Han C Kang 1 , Yong-Yeon Cho 1 , Hye S Lee 1 , Katherine A Fitzgerald 4 , Joo Y Lee 1
Affiliation
The NLRP 3 inflammasome is closely linked to the pathophysiology of a wide range of inflammatory diseases. This study was undertaken to identify small molecules that directly bind to NLRP 3 in order to develop pharmacologic interventions for NLRP 3‐related diseases.
中文翻译：
直接结合到NLRP3吡喃结构域，作为预防NLRP3驱动的炎症和痛风性关节炎的新策略。
NLRP 3炎性小体与多种炎性疾病的病理生理密切相关。进行这项研究以鉴定与NLRP 3直接结合的小分子，以便开发针对NLRP 3相关疾病的药理学干预措施。
更新日期：2020-03-05
中文翻译：
直接结合到NLRP3吡喃结构域，作为预防NLRP3驱动的炎症和痛风性关节炎的新策略。
NLRP 3炎性小体与多种炎性疾病的病理生理密切相关。进行这项研究以鉴定与NLRP 3直接结合的小分子，以便开发针对NLRP 3相关疾病的药理学干预措施。
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