Genome‐wide gene expression studies implicate macrophages as mediators of fibrosis in systemic sclerosis (SS c), but little is known about how these cells contribute to fibrotic activation in SS c. We undertook this study to characterize the activation profile of SS c monocyte‐derived macrophages and assessed their interaction with SS c fibroblasts.

中文翻译：

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系统性硬化症中人类巨噬细胞的促纤维化激活。

全基因组基因表达研究表明巨噬细胞是系统性硬化症 (SS c) 中纤维化的介质，但对这些细胞如何促进 SS c 中的纤维化活化知之甚少。我们进行了这项研究来表征 SS c 单核细胞衍生的巨噬细胞的激活特征，并评估它们与 SS c 成纤维细胞的相互作用。