Separation and characterization of unknown impurities in rutin tablets using trap‐free two‐dimensional liquid chromatography coupled with ion trap/time‐of‐flight mass spectrometry,Rapid Communications in Mass Spectrometry

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Separation and characterization of unknown impurities in rutin tablets using trap‐free two‐dimensional liquid chromatography coupled with ion trap/time‐of‐flight mass spectrometry
Rapid Communications in Mass Spectrometry ( IF 1.8 ) Pub Date : 2020-03-05 , DOI: 10.1002/rcm.8739
Jian Wang _{1,

2} , Xiaojuan Ren ₁ , Chunmei Wen ₁ , Yu Xu ₁ , Yue Chen ₂

Affiliation

A new high‐performance liquid chromatography method was developed for the determination of impurities in rutin tablets to improve on the method of the official monograph in national drug standards. Five impurities in rutin tablets were characterized using trap‐free two‐dimensional liquid chromatography coupled with ion trap/time‐of‐flight mass spectrometry (2D‐LC/IT‐TOFMS) in both positive and negative ion modes of electrospray ionization.

中文翻译：

使用无阱二维液相色谱-离子阱/飞行时间质谱法分离和鉴定芦丁片剂中的未知杂质

开发了一种新的高效液相色谱法，用于测定芦丁片剂中的杂质，以改进国家药品标准中官方专着的方法。使用无阱二维液相色谱结合离子阱/飞行时间质谱（2D-LC / IT-TOFMS），以电喷雾电离的正离子和负离子模式对芦丁片剂中的五种杂质进行了表征。

更新日期：2020-03-05

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