Activatable Molecular Probes for Second Near-Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging.,Angewandte Chemie International Edition

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Activatable Molecular Probes for Second Near-Infrared Fluorescence, Chemiluminescence, and Photoacoustic Imaging.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2020-03-05 , DOI: 10.1002/anie.202001783
Jiaguo Huang ₁ , Kanyi Pu ₁

Affiliation

Optical imaging plays a crucial role in biomedicine. However, due to strong light scattering and autofluorescence in biological tissue between 650–900 nm, conventional optical imaging often has a poor signal‐to‐background ratio and shallow penetration depth, which limits its ability in deep‐tissue in vivo imaging. Second near‐infrared fluorescence, chemiluminescence, and photoacoustic imaging modalities mitigate these issues by their respective advantages of minimized light scattering, eliminated external excitation, and ultrasound detection. To enable disease detection, activatable molecular probes (AMPs) with the ability to change their second near‐infrared fluorescence, chemiluminescence, or photoacoustic signals in response to a biomarker have been developed. This Minireview summarizes the molecular design strategies, sensing mechanisms, and imaging applications of AMPs. The potential challenges and perspectives of AMPs in deep‐tissue imaging are also discussed.

中文翻译：

用于第二近红外荧光，化学发光和光声成像的可激活分子探针。

光学成像在生物医学中起着至关重要的作用。但是，由于在650-900 nm之间的生物组织中有很强的光散射和自发荧光，传统的光学成像通常具有较差的信噪比和较浅的穿透深度，这限制了其在体内深层成像中的能力。第二种近红外荧光，化学发光和光声成像模式通过其各自的优点（最小化光散射，消除了外部激发和超声检测）缓解了这些问题。为了能够进行疾病检测，已经开发了具有可响应于生物标记改变其第二近红外荧光，化学发光或光声信号的能力的可激活分子探针（AMP）。这份Minireview总结了分子设计策略，传感机制，以及AMP的成像应用。还讨论了AMP在深层组织成像中的潜在挑战和前景。

更新日期：2020-03-05

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