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Nidulaxanthone A, a xanthone dimer with a heptacyclic 6/6/6/6/6/6/6 ring system from Aspergillus sp.-F029
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-03-05 , DOI: 10.1039/d0qo00113a
Fuqian Wang 1, 2, 3, 4 , Jie Jiang 1, 2, 3, 4 , Song Hu 1, 2, 3, 4 , Xincai Hao 5, 6, 7 , You-sheng Cai 4, 8, 9, 10, 11 , Ying Ye 12, 13, 14, 15, 16 , Haoran Ma 1, 2, 3, 4 , Weiguang Sun 12, 13, 14, 15, 16 , Lu Cheng 1, 2, 3, 4 , Chuanqi Huang 1, 2, 3, 4 , Hucheng Zhu 12, 13, 14, 15, 16 , Hong Zhang 1, 2, 3, 4 , Geng Zhang 1, 2, 3, 4 , Yonghui Zhang 12, 13, 14, 15, 16
Affiliation  

Nidulaxanthone A (1), a xanthone dimer bearing an unprecedented heptacyclic 6/6/6/6/6/6/6 system, together with a new monomeric nidulalin D (2) and four known analogues (3, 4, 5 and 6), were isolated from Aspergillus sp. F029. Biosynthetically, 1 was likely generated via [4 + 2] cycloaddition of precursor 3. Compounds 1, 2, and 3 exhibited cytotoxicity with IC50 values ranging from 3.2 to 21.9 μM, and antibacterial activity with MIC50 values of 13.2 and 19.6 μg ml−1 for 2 and 3, respectively.

中文翻译:

Nidulaxanthone A,一种具有七环6/6/6/6/6/6/6环系统的黄酮二聚体,来自Aspergillus sp.-F029

Nidulaxanthone A(1),呫吨酮二聚体轴承前所未有的七环6/6/6/6/6/6/6系统,一起用新的单体nidulalin d(2)和四个已知类似物(3456),分离自曲霉菌。F029。生物合成,1很可能产生通过[4 + 2]的前体的环加成3。化合物12,和3与IC展出的细胞毒性50值范围从3.2至21.9微米,并且抗菌活性与MIC 50分别为23的13.2和19.6μgml -1值。
更新日期:2020-04-24
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