Nidulaxanthone A, a xanthone dimer with a heptacyclic 6/6/6/6/6/6/6 ring system from Aspergillus sp.-F029,Organic Chemistry Frontiers

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Nidulaxanthone A, a xanthone dimer with a heptacyclic 6/6/6/6/6/6/6 ring system from Aspergillus sp.-F029
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2020-03-05 , DOI: 10.1039/d0qo00113a
Fuqian Wang _{1,

2,

3,

4} , Jie Jiang _{1,

2,

3,

4} , Song Hu _{1,

2,

3,

4} , Xincai Hao _{5,

6,

7} , You-sheng Cai _{4,

8,

9,

10,

11} , Ying Ye _{12,

13,

14,

15,

16} , Haoran Ma _{1,

2,

3,

4} , Weiguang Sun _{12,

13,

14,

15,

16} , Lu Cheng _{1,

2,

3,

4} , Chuanqi Huang _{1,

2,

3,

4} , Hucheng Zhu _{12,

13,

14,

15,

16} , Hong Zhang _{1,

2,

3,

4} , Geng Zhang _{1,

2,

3,

4} , Yonghui Zhang _{12,

13,

14,

15,

16}

Affiliation

Department of Pharmacy
Wuhan No. 1 Hospital
Wuhan 430022
People's Republic of China
College of Pharmacy Hubei University of Medicine
Shiyan 442000
China
Institute of TCM and Natural Products
School of Pharmaceutical Sciences
Wuhan University
Wuhan 430071
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation
School of Pharmacy
Tongji Medical College
Huazhong University of Science and Technology
Wuhan 430030

Nidulaxanthone A (1), a xanthone dimer bearing an unprecedented heptacyclic 6/6/6/6/6/6/6 system, together with a new monomeric nidulalin D (2) and four known analogues (3, 4, 5 and 6), were isolated from Aspergillus sp. F029. Biosynthetically, 1 was likely generated via [4 + 2] cycloaddition of precursor 3. Compounds 1, 2, and 3 exhibited cytotoxicity with IC₅₀ values ranging from 3.2 to 21.9 μM, and antibacterial activity with MIC₅₀ values of 13.2 and 19.6 μg ml⁻¹ for 2 and 3, respectively.

中文翻译：

Nidulaxanthone A，一种具有七环6/6/6/6/6/6/6环系统的黄酮二聚体，来自Aspergillus sp.-F029

Nidulaxanthone A（1），呫吨酮二聚体轴承前所未有的七环6/6/6/6/6/6/6系统，一起用新的单体nidulalin d（2）和四个已知类似物（3，4，5和6），分离自曲霉菌。F029。生物合成，1很可能产生通过[4 + 2]的前体的环加成3。化合物1，2，和3与IC展出的细胞毒性₅₀值范围从3.2至21.9微米，并且抗菌活性与MIC ₅₀分别为2和3的13.2和19.6μgml ^-1值。

更新日期：2020-04-24

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