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Ethnic Disparities in PET/CT Utilization at Diagnosis of Non-Small Cell Lung Cancer
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2020-03-05 , DOI: 10.1093/jnci/djaa034 Rustain L Morgan 1 , Sana D Karam 2 , Cathy J Bradley 3
中文翻译:
PET/CT 诊断非小细胞肺癌的种族差异
先前的研究表明,与肺癌治疗和结果相关的统计上存在显着的种族差异。我们研究了黑人、西班牙裔和非西班牙裔白人之间初始影像学和生存率的差异。
使用 2007 年至 2015 年链接的监测、流行病学和最终结果 - 医疗保险数据库来比较肺癌患者的初始成像方式。参与者包括 28,881 名非西班牙裔白人、3,123 名黑人和 1,907 名西班牙裔,年龄≥66 岁,参加了医疗保险付费服务并被诊断患有肺癌。主要结果是比较各组之间 PET/CT 的使用情况。次要结果是 12 个月癌症特异性生存率。分析中包括有关阶段、治疗和治疗设施的信息。卡方检验和逻辑回归用于评估与成像利用相关的因素。 Kaplan-Meier法和Cox比例风险回归用于计算调整风险比和生存率。所有统计检验都是双面的。
在调整人口、社区和设施特征后,与非西班牙裔白人相比,黑人在诊断时接受 PET/CT 成像的可能性较小,比值比 (OR) 为 0.54; 95% CI 0.50, 0.59; P < 0.001)。西班牙裔也不太可能接受 PET/CT 成像(OR 0.72;95% CI 0.65,0.81 P < 0.001)。 PET/CT 与生存率改善相关(HR = 0.61;95% CI:0.57, 0.65,P < 0.001)。
黑人和西班牙裔在诊断肺癌时不太可能接受指南推荐的 PET/CT 成像,这可能部分解释了生存率的差异。对这一问题的认识将使未来能够采取旨在缩小这种差距的干预措施。
更新日期:2020-03-05
Journal of the National Cancer Institute ( IF 9.9 ) Pub Date : 2020-03-05 , DOI: 10.1093/jnci/djaa034 Rustain L Morgan 1 , Sana D Karam 2 , Cathy J Bradley 3
Affiliation
Background
Prior research demonstrated statistically significant racial disparities related to lung cancer treatment and outcomes. We examined differences in initial imaging and survival between Blacks, Hispanics and non-Hispanic Whites.Methods
The linked Surveillance, Epidemiology, and End Results–Medicare database between 2007 and 2015 was used to compare initial imaging modality for patients with lung cancer. Participants included 28,881 non-Hispanic Whites, 3,123 Black, and 1,907 Hispanics, patients age ≥66 years who were enrolled in Medicare fee-for-service and diagnosed with lung cancer. The primary outcome was comparison of PET/CT utilization between groups. A secondary outcome was 12-month cancer specific survival. Information on stage, treatment, and treatment facility were included in the analysis. Chi-Square test and logistic regression were used to evaluate factors associated with imaging utilization. Kaplan-Meier method and Cox proportional hazards regression were used to calculate adjust hazard ratios and survival. All statistical tests were two-sided.Results
After adjusting for demographic, community, and facility characteristics, Blacks were less likely to undergo PET/CT imaging at diagnosis compared to non-Hispanic Whites odds ratio (OR) 0.54; 95% CI 0.50, 0.59; P < 0.001). Hispanics were also less likely to receive PET/CT imaging (OR 0.72; 95% CI 0.65, 0.81 P < 0.001). PET/CT was associated with improved survival (HR = 0.61; 95% CI: 0.57, 0.65, P < 0.001).Conclusion
Blacks and Hispanics are less likely to undergo guideline recommended PET/CT imaging at diagnosis of lung cancer, which may partially explain differences in survival. Awareness of this issue will allow for future interventions aimed at reducing this disparity.
中文翻译:
PET/CT 诊断非小细胞肺癌的种族差异
背景
先前的研究表明,与肺癌治疗和结果相关的统计上存在显着的种族差异。我们研究了黑人、西班牙裔和非西班牙裔白人之间初始影像学和生存率的差异。
方法
使用 2007 年至 2015 年链接的监测、流行病学和最终结果 - 医疗保险数据库来比较肺癌患者的初始成像方式。参与者包括 28,881 名非西班牙裔白人、3,123 名黑人和 1,907 名西班牙裔,年龄≥66 岁,参加了医疗保险付费服务并被诊断患有肺癌。主要结果是比较各组之间 PET/CT 的使用情况。次要结果是 12 个月癌症特异性生存率。分析中包括有关阶段、治疗和治疗设施的信息。卡方检验和逻辑回归用于评估与成像利用相关的因素。 Kaplan-Meier法和Cox比例风险回归用于计算调整风险比和生存率。所有统计检验都是双面的。
结果
在调整人口、社区和设施特征后,与非西班牙裔白人相比,黑人在诊断时接受 PET/CT 成像的可能性较小,比值比 (OR) 为 0.54; 95% CI 0.50, 0.59; P < 0.001)。西班牙裔也不太可能接受 PET/CT 成像(OR 0.72;95% CI 0.65,0.81 P < 0.001)。 PET/CT 与生存率改善相关(HR = 0.61;95% CI:0.57, 0.65,P < 0.001)。
结论
黑人和西班牙裔在诊断肺癌时不太可能接受指南推荐的 PET/CT 成像,这可能部分解释了生存率的差异。对这一问题的认识将使未来能够采取旨在缩小这种差距的干预措施。