Although cytomegaloviruses (CMVs) are species-specific, the study of nonhuman CMVs in animal models can help to inform and direct research aimed at developing a human CMV (HCMV) vaccine. Because the driving force behind the development of HCMV vaccines is to prevent congenital infection, the animal model in question must be one in which vertical transmission of virus occurs to the fetus. Fortunately, two such animal models—the rhesus macaque CMV and guinea pig CMV—are characterized by congenital infection. Hence, each model can be evaluated in “proof-of-concept” studies of preconception vaccination aimed at blocking transplacental transmission. This review focuses on similarities and differences in the respective model systems, and it discusses key insights from each model germane to the study of HCMV vaccines.

中文翻译：

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先天性巨细胞病毒传播的动物模型：对疫苗开发的影响。

尽管巨细胞病毒（CMV）是特定于物种的，但在动物模型中对非人类CMV的研究可有助于为旨在开发人类CMV（HCMV）疫苗的研究提供指导和指导。因为开发HCMV疫苗背后的驱动力是防止先天性感染，所以所讨论的动物模型必须是病毒向胎儿垂直传播的模型。幸运的是，以先天性感染为特征的两个这样的动物模型（恒河猴CMV和豚鼠CMV）。因此，可以在旨在阻止经胎盘传播的孕前疫苗的“概念验证”研究中评估每种模型。这篇综述着重于各个模型系统的异同，并讨论了每种模型与HCMV疫苗研究的关键见解。