It has been shown that many molecules released by adipose tissue (AT) into interstitial fluid can reach the bloodstream preferentially via lymphatic system. Worsened lymphatic drainage may alter interstitial fluid (ISF) composition and thus affect microenvironment of adipocytes. Nevertheless, the effect of lymphatic drainage on AT functions remains unknown. Therefore, we analyzed the lipolytic activity of femoral AT in two groups of premenopausal women similar in adiposity but differing in the efficiency of lymphatic drainage of lower body as assessed by lymphoscintigraphy. Levels of lipolytic markers were assessed in plasma and ISF collected by skin blister technique in femoral area. In addition, microdialysis was used to monitor lipolysis of AT in vivo. Our results indicate that worsened lymphatic drainage is associated with lower in vivo lipolytic index and reduced lipolytic responsiveness of femoral AT to adrenergic stimuli. Thus, efficiency of lymphatic drainage appears to play a role in the regulation of AT metabolism. Accordingly, worsened lymphatic drainage could contribute to the resistance of lower body AT to intentional weigh loss.

已经表明，脂肪组织 (AT) 释放到组织液中的许多分子可以优先通过淋巴系统到达血流。淋巴引流恶化可能会改变间质液 (ISF) 的成分，从而影响脂肪细胞的微环境。然而，淋巴引流对 AT 功能的影响仍然未知。因此，我们分析了两组肥胖程度相似但下半身淋巴引流效率不同的绝经前妇女的股骨 AT 的脂肪分解活性，如淋巴显像评估。在股骨区域通过皮肤水疱技术收集的血浆和 ISF 中评估脂解标志物的水平。此外，微透析用于监测体内 AT 的脂肪分解。我们的结果表明，淋巴引流恶化与体内脂肪分解指数降低和股骨 AT 对肾上腺素能刺激的脂肪分解反应降低有关。因此，淋巴引流效率似乎在调节 AT 代谢中起作用。因此，恶化的淋巴引流可能导致下半身 AT 对有意减肥的抵抗力。