BACKGROUND We examined the associations between accelerometry-measured physical activity (PA) and incidence of 13 cancers among a cohort of postmenopausal women. METHODS In this prospective study, 6382 women wore ActiGraph GT3X+ accelerometers at the hip for up to 7 days during 2012-2013, and were followed over a median of 4.7 years for diagnosis of 13 invasive cancers. Calibrated intensity cut points were used to define minutes per day of total, light and moderate-to-vigorous PA. We used multivariable Cox regression to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for tertiles, and one-standard deviation (SD) unit increments of PA exposures in relation to cancer incidence. We examined effect measure modification by age, race/ethnicity, body mass index and smoking history. RESULTS The highest (vs. lowest) tertiles of total, light and moderate-to-vigorous PA were associated with covariate-adjusted HRs of 0.72 (95% CI = 0.53-0.97), 0.81 (95% CI = 0.60-1.09) and 0.66 (95% CI = 0.48-0.91), respectively. In age-stratified analyses, HRs for total PA were lower among women <80 years (HRper one-SD = 0.75, 95% CI = 0.63-0.90) than among women ≥80 years (HRper one-SD = 0.99, 95% CI = 0.82-1.18) (PInteraction = 0.03). Race/ethnicity, BMI and smoking did not strongly modify these associations. CONCLUSIONS Engaging in physical activity may play a beneficial role in the prevention of certain cancers in older women.

中文翻译：

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加速度计测量的身体活动与老年女性身体活动相关癌症发病率的关联：来自 WHI OPACH 研究的结果。

背景 我们在一组绝经后妇女中检查了加速度计测量的身体活动 (PA) 与 13 种癌症发病率之间的关联。方法 在这项前瞻性研究中，6382 名女性在 2012 年至 2013 年间在髋部佩戴 ActiGraph GT3X+ 加速度计长达 7 天，中位随访时间为 4.7 年，诊断出 13 种浸润性癌症。校准的强度分界点用于定义每天总、轻度和中度至剧烈 PA 的分钟数。我们使用多变量 Cox 回归来估计三分位数的风险比 (HR) 和 95% 置信区间 (CI)，以及 PA 暴露与癌症发病率相关的一个标准差 (SD) 单位增量。我们检查了年龄、种族/民族、体重指数和吸烟史对效果测量的修改。结果总分的最高（与最低）三分位数，轻度和中度至剧烈的 PA 与协变量调整的 HR 相关，分别为 0.72 (95% CI = 0.53-0.97)、0.81 (95% CI = 0.60-1.09) 和 0.66 (95% CI = 0.48-0.91) . 在年龄分层分析中，<80 岁女性的总 PA 的 HR (HRper one-SD = 0.75, 95% CI = 0.63-0.90) 低于 80 岁以上的女性 (HRper one-SD = 0.99, 95% CI = 0.82-1.18) (PInteraction = 0.03)。种族/民族、BMI 和吸烟并没有强烈改变这些关联。结论 参与体育活动可能在预防老年妇女某些癌症方面发挥有益作用。80 岁（HRper one-SD = 0.75, 95% CI = 0.63-0.90）高于 ≥80 岁女性（HRper one-SD = 0.99, 95% CI = 0.82-1.18）（PInteraction = 0.03）。种族/民族、BMI 和吸烟并没有强烈改变这些关联。结论 参与体育活动可能在预防老年妇女某些癌症方面发挥有益作用。80 岁（HRper one-SD = 0.75, 95% CI = 0.63-0.90）高于 ≥80 岁女性（HRper one-SD = 0.99, 95% CI = 0.82-1.18）（PInteraction = 0.03）。种族/民族、BMI 和吸烟并没有强烈改变这些关联。结论 参与体育活动可能在预防老年妇女某些癌症方面发挥有益作用。