Personalized medicine should ideally be prescribed to every individual because of the unique characteristics (e.g., biological, physical, and medical) of each individual. It is, however, challenging to provide personalized medicine for the mass population of specific individuals effectively and efficiently. This manuscript describes a method of fabricating fully customizable drug tablets for personalized medicine by the 3D printing technology. This method involves the versatile fabrication of the tablets via the specifically designed 3D printed molds of different shapes and sizes, and an intuitive 1-dimensional release of drug that relates the shape of the drug-containing matrix to the release profile. The customization includes all the aspects of varying dosage, duration, release profiles, and combination of multiple drugs. In particular, it has previously been technically difficult to devise a single platform that fabricates carriers that release drug with any desired type of release profiles. This method of fabricating fully customizable tablets is simple, inexpensive, and efficient. Detailed selection and investigation of the materials ensured that the tablet and the method of fabrication are safe (e.g., biocompatible, FDA-approved ingredients used) and other desirable features (e.g., sustained release and high dosage) are achieved. These desirable characteristics of the method thus allow fully customizable drug tablets to be fabricated efficiently on the spot after the diagnosis of individual patients; at the same time, the method can be made widely accessible to the mass population. Hence, the concept of personalized medicine can truly be realized.

中文翻译：

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通过3D打印技术按需定制的完全可定制的药片，用于个性化药品。

理想情况下，由于每个人的独特特征（例如，生物学，物理和医学上的差异），应该为每个人开出个性化的药物。但是，有效地和高效地为大量特定人群提供个性化药物具有挑战性。该手稿描述了一种通过3D打印技术制造用于个性化药物的完全可定制药物片剂的方法。该方法涉及通过专门设计的具有不同形状和大小的3D打印模具来通用制造片剂，以及将包含药物的基质的形状与释放曲线相关联的直观的一维药物释放。定制包括变化剂量，持续时间，释放曲线以及多种药物组合的所有方面。尤其是，以前，在技术上很难设计出单一平台来制造能够以任何所需类型的释放曲线释放药物的载体。这种制造完全可定制的片剂的方法是简单，廉价和有效的。材料的详细选择和研究确保了片剂和制造方法的安全性（例如，生物相容性，使用的FDA批准的成分），并实现了其他所需的功能（例如，缓释和高剂量）。因此，该方法的这些理想特性使得可以在诊断出个别患者后，在现场有效地制造出完全可定制的药物片剂。同时，该方法可以使大众广泛使用。因此，个性化医学的概念可以真正实现。