Breast cancer contributes to high mortality rates as a result of metastasis. Tumor-derived exosomes facilitate the development of the premetastatic environment, interacting and inhibiting the normal function of immune cells, thereby forming an immunosuppressive microenvironment for tumor metastasis. Herein, the platelet and neutrophil hybrid cell membrane (PNM) was embellished on a gold nanocage (AuNC) surface called nanosponges and nanokillers (NSKs). NSKs can simultaneously capture and clear the circulating tumor cells (CTCs) and tumor-derived exosomes via high-affinity membrane adhesion receptors, effectively cutting off the connection between exosomes and immune cells. Bionic NSK is loaded with doxorubicin (DOX) and indocyanine green (ICG) for synergic chemo-photothermal therapy. NSKs show greater cellular uptake, deeper tumor penetration, and higher cytotoxicity to tumor cells in comparison to non-coated AuNCs or single-coated AuNCs in vitro. In vivo, the multipurpose NSKs could not only completely ablate the primary tumor but also inhibit breast cancer metastasis with high efficiency in xenograft and orthotopic breast tumor-bearing models. Thus, NSKs could be a promising nanomedicine for the future clinical intervention of breast cancer metastasis.

乳腺癌由于转移而导致高死亡率。肿瘤来源的外来体促进转移前环境的发展，相互作用并抑制免疫细胞的正常功能，从而形成用于肿瘤转移的免疫抑制性微环境。在本文中，血小板和嗜中性粒细胞杂交细胞膜（PNM）装饰在称为nanosponges and nanokillers（NSKs）的金纳米笼（AuNC）表面上。NSK可以通过高亲和力膜粘附受体同时捕获并清除循环中的肿瘤细胞（CTC）和肿瘤来源的外泌体，从而有效切断外泌体与免疫细胞之间的联系。仿生NSK装有阿霉素（DOX）和吲哚菁绿（ICG）用于协同化学光热疗法。NSKs表现出更大的细胞摄取，更深的肿瘤渗透，体外。在体内，多用途NSKs不仅可以完全消融原发性肿瘤，而且在异种移植和原位乳腺荷瘤模型中也可以高效抑制乳腺癌的转移。因此，NSKs可能是未来乳腺癌转移临床干预的有前途的纳米药物。