Objectives

The association between Interleukin (IL)-17A and IL-17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17F gene polymorphism with ankylosing spondylitis (AS), osteoarthritis (OA) and rheumatoid arthritis (RA).

Methods

We searched Medline up to August 2019. The summary Odds Ratio (OR) with corresponding 95% confidence intervals (CIs) was calculated to evaluate the relationship between IL-17A and IL-17F gene polymorphism with genetic susceptibility of AS, OA and RA.

Results

A total of 19 studies with 5298 cases and 5675 healthy controls were included. There were significant associations between rs2275913 G allele with OA, RA susceptibility (P < .05) but not AS. Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to AS and OA in Caucasian populations (P < .001) but not Mongolians. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P < .05).

Conclusion

IL-17F gene rs763780 C allele confers increased risk of inflammatory arthritis in Caucasians; IL-17A gene rs2275913 G allele are protective for OA susceptibility in Mongolians. More well-designed studies with larger sample size are needed to elucidate the role of IL-17A gene rs2275913 G allele in inflammatory arthritis, especially AS.

中文翻译：

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IL-17A和IL-17F基因多态性与炎性关节炎易感性的关联：一项荟萃分析

目标

在先前的研究中，白介素（IL）-17A和IL-17F基因多态性与炎性关节炎之间的关联是不一致的。这项荟萃分析旨在确定IL-17A和IL-17F基因多态性与强直性脊柱炎（AS），骨关节炎（OA）和类风湿性关节炎（RA）之间的关联。

方法

我们搜索了截至2019年8月的Medline。计算了总的几率（OR）和相应的95％置信区间（CIs），以评估IL-17A和IL-17F基因多态性与AS，OA和RA的遗传易感性之间的关系。

结果

总共包括19项研究，涉及5298例病例和5675例健康对照者。rs2275913 G等位基因与OA，RA易感性之间存在显着相关性（P  <.05），而与AS无相关性。按种族进行的亚组分析表明，在白种人中，rs763780 C等位基因与AS和OA密切相关（P  <.001），而蒙古族则不然。在白种人人群中，rs763780与RA易感性之间存在显着相关性（P  <.05）。

结论

IL-17F基因rs763780 C等位基因使白种人发炎性关节炎的风险增加；IL-17A基因rs2275913 G等位基因在蒙古族人群中对OA易感性具有保护作用。需要进行更大样本量的更精心设计的研究，以阐明IL-17A基因rs2275913 G等位基因在炎症性关节炎（尤其是AS）中的作用。