当前位置：
X-MOL 学术
›
Colloids Surf. B Biointerfaces
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Poly(2-oxazoline)-based magnetic hydrogels: Synthesis, performance and cytotoxicity.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.colsurfb.2020.110912 Martin Cvek 1 , Anna Zahoranova 2 , Miroslav Mrlik 1 , Petra Sramkova 2 , Antonin Minarik 3 , Michal Sedlacik 4
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.colsurfb.2020.110912 Martin Cvek 1 , Anna Zahoranova 2 , Miroslav Mrlik 1 , Petra Sramkova 2 , Antonin Minarik 3 , Michal Sedlacik 4
Affiliation
|
Research on the subject of smart biomaterials has become a cornerstone of tissue engineering and regenerative medicine. Herein, the authors report on developing magnetic hydrogels that combine high biocompatibility and remarkable activity in magnetic fields. We fabricated magnetic hydrogels based on poly(2-ethyl-2-oxazoline) (POx) via living ring-opening cationic polymerization with in-situ embedding of the carbonyl iron (CI) particles. Investigation was made as to the effect exerted by the concentration of CI on magnetic, viscoelastic/magnetorheological properties, the degree of equilibrium swelling, and cytotoxicity. The hydrogels exhibited an open pore structure, as evidenced by computed tomography (CT) imaging. Susceptibility measurements revealed the concentration-dependent field-induced particle restructuration indicating elongation/contraction of the material, thereby determining the potential for magneto-mechanical stimulation of the cells. The POx-based magnetic hydrogels were amphiphilic in character, showing decrease in their capability to hold liquid alongside increase in CI concentration. Viscoelastic measurements suggested that interaction occurred between the particles and matrix based on inconsistency between the experimental storage modulus and the Krieger-Dougherty model. The synthesized materials exhibited excellent biocompatibility toward the 3T3 fibroblast cell line in tests of extract toxicity and direct contact cytotoxicity (ISO standards). The unique combination of properties exhibited by the material - magneto-mechanical activity and biocompatibility - could prove favorable in fields such as biomedicine and biomechanics.
中文翻译：
聚（2-恶唑啉）基磁性水凝胶：合成，性能和细胞毒性。
关于智能生物材料的研究已经成为组织工程和再生医学的基石。在此，作者报告了开发结合了高生物相容性和在磁场中具有显着活性的磁性水凝胶。我们通过活性开环阳离子聚合和羰基铁（CI）粒子的原位嵌入，制造了基于聚（2-乙基-2-恶唑啉）（POx）的磁性水凝胶。研究了CI浓度对磁性，粘弹性/磁流变性质，平衡溶胀度和细胞毒性的影响。如通过计算机断层扫描（CT）成像所证明的，水凝胶显示出开孔结构。磁化率测量揭示了浓度依赖性场诱导的颗粒结构变化，表明材料的伸长/收缩，从而确定了对细胞进行磁机械刺激的潜力。基于POx的磁性水凝胶具有两亲性，显示其保持液体的能力下降，同时CI浓度增加。粘弹性测量表明，基于实验储能模量与Krieger-Dougherty模型之间的不一致，颗粒与基质之间发生了相互作用。在提取物毒性和直接接触细胞毒性（ISO标准）测试中，合成的材料对3T3成纤维细胞系表现出极好的生物相容性。
更新日期：2020-03-05
中文翻译：
聚（2-恶唑啉）基磁性水凝胶：合成，性能和细胞毒性。
关于智能生物材料的研究已经成为组织工程和再生医学的基石。在此，作者报告了开发结合了高生物相容性和在磁场中具有显着活性的磁性水凝胶。我们通过活性开环阳离子聚合和羰基铁（CI）粒子的原位嵌入，制造了基于聚（2-乙基-2-恶唑啉）（POx）的磁性水凝胶。研究了CI浓度对磁性，粘弹性/磁流变性质，平衡溶胀度和细胞毒性的影响。如通过计算机断层扫描（CT）成像所证明的，水凝胶显示出开孔结构。磁化率测量揭示了浓度依赖性场诱导的颗粒结构变化，表明材料的伸长/收缩，从而确定了对细胞进行磁机械刺激的潜力。基于POx的磁性水凝胶具有两亲性，显示其保持液体的能力下降，同时CI浓度增加。粘弹性测量表明，基于实验储能模量与Krieger-Dougherty模型之间的不一致，颗粒与基质之间发生了相互作用。在提取物毒性和直接接触细胞毒性（ISO标准）测试中，合成的材料对3T3成纤维细胞系表现出极好的生物相容性。
京公网安备 11010802027423号