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PLA/β-CD-based fibres loaded with quercetin as potential antibacterial dressing materials.
Colloids and Surfaces B: Biointerfaces ( IF 5.4 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.colsurfb.2020.110949
Bartłomiej Kost 1 , Mariia Svyntkivska 1 , Marek Brzeziński 1 , Tomasz Makowski 1 , Ewa Piorkowska 1 , Katarzyna Rajkowska 2 , Alina Kunicka-Styczyńska 2 , Tadeusz Biela 1
Affiliation  

Microbial infections lead to elevated inflammatory responses, which usually result in prolonged and incomplete wound healing. Therefore, there is an increasing demand for biodegradable fibres that are effective against a different range of microorganisms, especially those with antibiotic resistance. Herein, quercetin-(Q)-loaded polylactide-based fibres were developed using the electrospinning technique. Since Q exhibits low chemical stability, we used star-shaped polylactides (PLAs) with a β-CD core to host Q by inclusion complexation. To enhance the stability of the fibres and additionally entrap the Q between polymeric chains, we adapted supramolecular cross-linking by the stereocomplexation of PLAs with opposite configurations. As a control, we prepared an additional formulation of star-shaped/commercial PLA/Q for the preparation of nonwovens in which the β-CD moiety was not present. All developed fibres were smooth and continuous, with an average diameter of 37 μm. Although nonwovens did not possess diffusible activity, good antibacterial effects against Staphylococcus aureus (S. aureus), Escherichia coli (E.coli) and Klebsiella pneumoniae (K. pneumoniae) were observed. All these features validate the proposed approach, in which different supramolecular interactions were used to modify the properties of PLA-based fibres and, most importantly, show their great potential usefulness against microbial infections.

中文翻译:

含有槲皮素的PLA /β-CD基纤维可作为潜在的抗菌敷料。

微生物感染导致炎症反应增强,通常导致伤口愈合时间延长和不完全。因此,对可有效抵抗不同范围的微生物,特别是具有抗生素抗性的微生物的可生物降解纤维的需求日益增长。在此,使用静电纺丝技术开发了槲皮素-(Q)-负载的聚丙交酯基纤维。由于Q表现出较低的化学稳定性,因此我们使用具有β-CD核的星形聚丙交酯(PLA)通过包合络合来承载Q。为了增强纤维的稳定性并使Q截留在聚合物链之间,我们通过具有相反构型的PLA的立体络合适应了超分子交联。作为对照,我们制备了星形/商用PLA / Q的另一种配方,用于制备其中不存在β-CD部分的无纺布。所有显影的纤维均光滑且连续,平均直径为37μm。尽管非织造布不具有扩散活性,但观察到对金黄色葡萄球菌(S. aureus),大肠杆菌(E.coli)和肺炎克雷伯菌(Klebsiella pneumoniae)(K。pneumoniae)具有良好的抗菌作用。所有这些特征验证了所提出的方法,其中使用了不同的超分子相互作用来修饰基于PLA的纤维的特性,最重要的是,显示了它们对微生物感染的巨大潜在用途。尽管非织造布不具有扩散活性,但是观察到对金黄色葡萄球菌(S. aureus),大肠杆菌(E.coli)和肺炎克雷伯菌(Klebsiella pneumoniae)(K. pneumoniae)有良好的抗菌作用。所有这些特征验证了所提出的方法,其中使用了不同的超分子相互作用来修饰基于PLA的纤维的特性,最重要的是,显示了它们对微生物感染的巨大潜在用途。尽管非织造布不具有扩散活性,但是观察到对金黄色葡萄球菌(S. aureus),大肠杆菌(E.coli)和肺炎克雷伯菌(Klebsiella pneumoniae)(K. pneumoniae)有良好的抗菌作用。所有这些特征验证了所提出的方法,其中使用了不同的超分子相互作用来修饰基于PLA的纤维的特性,最重要的是,显示了它们对微生物感染的巨大潜在用途。
更新日期:2020-03-05
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