In March 2019, SmartTots, a public-private partnership between the US Food and Drug Administration and the International Anesthesia Research Society, hosted a meeting attended by research experts, anaesthesia journal editors, and government agency representatives to discuss the continued need for rigorous preclinical research and the importance of establishing reporting standards for the field of anaesthetic perinatal neurotoxicity. This group affirmed the importance of preclinical research in the field, and welcomed novel and mechanistic approaches to answer some of the field's largest questions. The attendees concluded that summarising the benefits and disadvantages of specific model systems, and providing guidance for reporting results, would be helpful for designing new experiments and interpreting results across laboratories. This expert opinion report is a summary of these discussions, and includes a focused review of current animal models and reporting standards for the field of perinatal anaesthetic neurotoxicity. This will serve as a practical guide and road map for novel and rigorous experimental work.

中文翻译：

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临床前研究和发育性麻醉剂神经毒性出版物的标准：SmartTots临床前工作组的专家意见声明。

2019年3月，美国食品和药物管理局与国际麻醉研究协会之间的公私合作伙伴SmartTots主持了一次由研究专家，麻醉杂志编辑和政府机构代表参加的会议，讨论了继续进行严格的临床前研究的必要性以及建立麻醉围产期神经毒性领域报告标准的重要性。该小组肯定了该领域临床前研究的重要性，并欢迎新颖且机械的方法来回答该领域一些最大的问题。与会者得出的结论是，总结特定模型系统的优缺点，并为报告结果提供指导，将有助于设计新的实验并解释各个实验室的结果。这份专家意见报告是对这些讨论的总结，并包括对围产期麻醉神经毒性领域当前动物模型和报告标准的重点综述。这将作为新颖而严格的实验工作的实用指南和路线图。