Receptor tyrosine kinases (RTK) are transmembrane kinases that receive signals for intercellular communication to help organize body plan and sustain tissue homeostasis. These signals converge into the major signaling module of ERK, which transduces signals to the cytoplasm and nucleus. How this module responds to multiple RTK signals, and specifies unique outcomes in each cell, is still poorly understood. Recent technological advances in the quantitative imaging of ERK activity and its manipulation have yielded significant information on the cellular logic behind ERK activation and its readout in the context of Drosophila development. While in the pregastrulation stage, ERK plays a decisive on/off switch; its role changes to modulatory functions of morphogenesis and tissue quality control in the late embryonic stages.

中文翻译：

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果蝇的形态发生和稳态中的ERK信号动力学。

受体酪氨酸激酶（RTK）是跨膜激酶，可接收细胞间通讯信号，帮助组织身体计划并维持组织稳态。这些信号汇聚到ERK的主要信号模块中，该模块将信号转导至细胞质和细胞核。该模块如何响应多个RTK信号，并在每个单元格中指定独特的结果，仍然知之甚少。在ERK活性及其操作的定量成像方面的最新技术进展已获得了有关果蝇发育过程中ERK激活及其读出背后的细胞逻辑的重要信息。在准备阶段，ERK起到决定性的开/关开关作用；它的作用在胚胎后期改变了形态发生的调节功能和组织质量控制。