Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric diseases that are characterized by abnormalities of thought, behaviour, cognition and mood. The genetic findings obtained from past molecular genetics research failed to elucidate the molecular pathogenesis of SZ and BD and this situation showed that the risk factors for these diseases were not solely due to the DNA sequence. On the other hand, evidence from cell, animal and postmortem brain studies suggest that abnormal epigenetic mechanisms are important actors in the etiology of complex diseases such as SZ and BD. In this review, epigenetic evidences that obtained from DNA methylation, post-translational histone modifications and non-coding RNA studies in SZ and BD were summarized and the importance of this evidences for advances in the diagnosis and treatment of SZ and BD were discussed briefly.

中文翻译：

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解决重大精神病之谜的线索：精神分裂症和双相情感障碍的表观遗传基础。

精神分裂症（SZ）和躁郁症（BD）是严重的精神疾病，其特征在于思维，行为，认知和情绪异常。从过去的分子遗传学研究中获得的遗传发现未能阐明SZ和BD的分​​子发病机理，这种情况表明这些疾病的危险因素不仅是DNA序列引起的。另一方面，来自细胞，动物和死后脑研究的证据表明，异常的表观遗传机制是诸如SZ和BD等复杂疾病的病因学中的重要角色。在这篇评论中，从DNA甲基化获得的表观遗传证据，