In 2019, the International Agency for Research on Cancer (IARC) "Preamble to the IARC Monographs" expanded guidance regarding the scientific approaches that should be employed in its monographs. These amendments to the monograph development process are an improvement but still fall short in several areas. While the revised Preamble lays out broad methods and approaches to evaluate scientific evidence, there is a lack of specificity with regard to how IARC Working Groups will conduct consistent evaluations in a standardized, objective, and transparent manner; document systematic review and evidence integration actions, and substantiate how these actions and decisions inform the ultimate classifications. Furthermore, no guidance is provided to ensure Working Groups consistently incorporate mechanistic evidence in a robust manner using a defined approach in the context of 21st century knowledge of modes of action. Nor are the conclusions of the working groups subjected to outside, independent scientific peer review. Continued improvements and modernization of the procedures for evaluating, presenting, and communicating study quality, and in the methods used to conduct and peer-review evidence-based decision making will benefit the Working Group members, the IARC Monographs Programme overall, and the international regulatory community and public who rely upon the monographs.

中文翻译：

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为改进国际癌症研究机构（IARC）专着计划而提出的进一步修订建议。

在2019年，国际癌症研究机构（IARC）的“ IARC专论序言”扩大了有关应在其专论中采用的科学方法的指南。对专着发展过程的这些修正是一种改进，但在某些方面仍然不足。尽管修订后的序言提出了评估科学证据的广泛方法和方法，但在IARC工作组如何以标准化，客观和透明的方式进行一致的评估方面，尚缺乏具体性；记录系统的审查和证据整合措施，并证实这些措施和决定如何告知最终分类。此外，没有提供指导以确保工作组在21世纪的行动方式知识的背景下使用定义的方法始终如一地以可靠的方式纳入机械证据。工作组的结论也不受外部独立的科学同行审查。评估，陈述和交流研究质量的程序的持续改进和现代化，以及用于进行和同行评审循证决策的方法，将使工作组成员，IARC专论计划整体以及国际法规受益。依靠专着的社区和公众。