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Systematic Integration of Structural and Functional Data into Multi-scale Models of Mouse Primary Visual Cortex.
Neuron ( IF 14.7 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.neuron.2020.01.040 Yazan N Billeh 1 , Binghuang Cai 1 , Sergey L Gratiy 1 , Kael Dai 1 , Ramakrishnan Iyer 1 , Nathan W Gouwens 1 , Reza Abbasi-Asl 2 , Xiaoxuan Jia 1 , Joshua H Siegle 1 , Shawn R Olsen 1 , Christof Koch 1 , Stefan Mihalas 1 , Anton Arkhipov 1
Neuron ( IF 14.7 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.neuron.2020.01.040 Yazan N Billeh 1 , Binghuang Cai 1 , Sergey L Gratiy 1 , Kael Dai 1 , Ramakrishnan Iyer 1 , Nathan W Gouwens 1 , Reza Abbasi-Asl 2 , Xiaoxuan Jia 1 , Joshua H Siegle 1 , Shawn R Olsen 1 , Christof Koch 1 , Stefan Mihalas 1 , Anton Arkhipov 1
Affiliation
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Structural rules underlying functional properties of cortical circuits are poorly understood. To explore these rules systematically, we integrated information from extensive literature curation and large-scale experimental surveys into a data-driven, biologically realistic simulation of the awake mouse primary visual cortex. The model was constructed at two levels of granularity, using either biophysically detailed or point neurons. Both variants have identical network connectivity and were compared to each other and to experimental recordings of visual-driven neural activity. While tuning these networks to recapitulate experimental data, we identified rules governing cell-class-specific connectivity and synaptic strengths. These structural constraints constitute hypotheses that can be tested experimentally. Despite their distinct single-cell abstraction, both spatially extended and point models perform similarly at the level of firing rate distributions for the questions we investigated. All data and models are freely available as a resource for the community.
中文翻译：
系统地将结构和功能数据集成到鼠标初级视觉皮层的多尺度模型中。
皮质回路功能特性的结构规则了解得很少。为了系统地探索这些规则，我们将来自大量文献管理和大规模实验调查的信息整合到了数据驱动的，生物学上逼真的清醒小鼠初级视觉皮层的模拟中。使用生物物理详细信息或点神经元在两个粒度级别上构建模型。两种变体具有相同的网络连通性，并且相互比较并与视觉驱动的神经活动的实验记录进行了比较。在调整这些网络以概括实验数据时，我们确定了控制特定于细胞类的连接性和突触强度的规则。这些结构性约束构成可以通过实验进行检验的假设。尽管它们具有独特的单细胞抽象概念，但在我们研究的问题上，空间扩展模型和点模型在发射速率分布级别上的性能相似。所有数据和模型都可以作为社区资源免费获得。
更新日期：2020-03-05
中文翻译：
系统地将结构和功能数据集成到鼠标初级视觉皮层的多尺度模型中。
皮质回路功能特性的结构规则了解得很少。为了系统地探索这些规则，我们将来自大量文献管理和大规模实验调查的信息整合到了数据驱动的，生物学上逼真的清醒小鼠初级视觉皮层的模拟中。使用生物物理详细信息或点神经元在两个粒度级别上构建模型。两种变体具有相同的网络连通性，并且相互比较并与视觉驱动的神经活动的实验记录进行了比较。在调整这些网络以概括实验数据时，我们确定了控制特定于细胞类的连接性和突触强度的规则。这些结构性约束构成可以通过实验进行检验的假设。尽管它们具有独特的单细胞抽象概念，但在我们研究的问题上，空间扩展模型和点模型在发射速率分布级别上的性能相似。所有数据和模型都可以作为社区资源免费获得。
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