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Too Much Tau in Interneurons Impairs Adult Hippocampal Neurogenesis in Alzheimer's Disease.
Cell Stem Cell ( IF 19.8 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.stem.2020.02.004
Ramsey Najm 1 , Antara Rao 1 , Yadong Huang 2
Affiliation  

Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer’s disease (AD) is essential for unravelling its role in pathogenesis. In this issue of Cell Stem Cell, Zheng et al. (2020) report that human tau accumulation in dentate gyrus GABAergic interneurons disrupts AHN and strengthening GABAergic signaling restores AHN and improves cognition in an AD mouse model.



中文翻译:

中间神经元中过多的 Tau 会损害阿尔茨海默病中的成人海马神经发生。

了解为什么成人海马神经发生 (AHN) 在阿尔茨海默病 (AD) 中受损对于揭示其在发病机制中的作用至关重要。在本期Cell Stem Cell中,Zheng 等人。(2020) 报告说,人类 tau 在齿状回 GABA 能中间神经元中的积累会破坏 AHN,而加强 GABA 能信号可以恢复 AHN 并改善 AD 小鼠模型的认知。

更新日期:2020-03-05
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