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Divide and Rule: Mitochondrial Fission Regulates Quiescence in Hematopoietic Stem Cells.
Cell Stem Cell ( IF 19.8 ) Pub Date : 2020-03-05 , DOI: 10.1016/j.stem.2020.02.009
Tiago C Luis 1 , Hannah Lawson 2 , Kamil R Kranc 2
Affiliation  

Hematopoietic stem cells (HSCs) remain quiescent to preserve long-term integrity. In this issue of Cell Stem Cell, Hinge et al. (2020) and Liang et al. (2020) demonstrate that HSCs achieve this by regulating mitochondrial fission and lysosomal activity, suppressing glucose uptake, and maintaining healthy punctate mitochondria with low metabolic activity.



中文翻译:


分而治之:线粒体裂变调节造血干细胞的静止。



造血干细胞 (HSC) 保持静止状态以保持长期完整性。在本期《细胞干细胞》中,Hinge 等人。 (2020)和梁等人。 (2020) 证明 HSC 通过调节线粒体裂变和溶酶体活性、抑制葡萄糖摄取以及维持低代谢活性的健康点状线粒体来实现这一目标。

更新日期:2020-03-05
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