Manipulating the microbiome has enormous potential to treat important human diseases. Microbiome surveys are often used to identify potential therapeutic targets by finding associations between microbial elements and disease status. We argue that many reported associations between the microbiome and disease are incompatible with translational research because they are insufficiently specific. We encourage the clear specification of manipulable microbial elements that can be tested in follow-up randomized experiments, and we provide multiple examples of specific and nonspecific microbial elements.

中文翻译：

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从微生物组调查中促进翻译进步的策略。

操纵微生物组具有治疗重要人类疾病的巨大潜力。微生物组调查通常用于通过发现微生物元素与疾病状况之间的关联来确定潜在的治疗靶标。我们认为微生物组和疾病之间的许多报道关联与翻译研究不相容，因为它们的特异性不足。我们鼓励对可操作的微生物元素制定明确的规范，以便在后续随机实验中进行测试，并且提供了特定和非特定微生物元素的多个示例。