Human aging is a phenomenon of gradual decline and loss of cell, tissue, organ and other functions under the action of external environment and internal factors. It is mainly related to genomic instability, telomere wear, mitochondrial dysfunction, protein balance disorder, antioxidant damage, microRNA expression disorder and so on. Sirtuins protein is a kind of deacetylase which can regulate cell metabolism and participate in a variety of cell physiological functions. It has been found that sirtuins family can prolong the lifespan of yeast. Sirtuins can inhibit human aging through many signaling pathways, including apoptosis signaling pathway, mTOR signaling pathway, sirtuins signaling pathway, AMPK signaling pathway, phosphatidylinositol 3 kinase (PI3K) signaling pathway and so on. Based on this, this paper reviews the action principle of anti-aging star members of sirtuins family Sirt1, Sirt3 and Sirt6 on anti-aging related signaling pathways and typical compounds, in order to provide ideas for the screening of anti-aging compounds of sirtuins family members.

人的衰老是在外部环境和内部因素的作用下，细胞，组织，器官等功能逐渐衰退和丧失的现象。它主要与基因组不稳定，端粒磨损，线粒体功能障碍，蛋白质平衡紊乱，抗氧化损伤，microRNA表达紊乱等有关。Sirtuins蛋白是一种脱乙酰基酶，可以调节细胞代谢并参与多种细胞生理功能。已经发现sirtuins家族可以延长酵母的寿命。Sirtuins可以通过许多信号通路抑制人类衰老，包括凋亡信号通路，mTOR信号通路，sirtuins信号通路，AMPK信号通路，磷脂酰肌醇3激酶（PI3K）信号通路等。基于此，