Objectives To evaluate the associations of habitual fish oil supplementation with cardiovascular disease (CVD) and mortality in a large prospective cohort.
Design Population based, prospective cohort study.
Setting UK Biobank.
Participants A total of 427 678 men and women aged between 40 and 69 who had no CVD or cancer at baseline were enrolled between 2006 and 2010 and followed up to the end of 2018.
Main exposure All participants answered questions on the habitual use of supplements, including fish oil.
Main outcome measures All cause mortality, CVD mortality, and CVD events.
Results At baseline, 133 438 (31.2%) of the 427 678 participants reported habitual use of fish oil supplements. The multivariable adjusted hazard ratios for habitual users of fish oil versus non-users were 0.87 (95% confidence interval 0.83 to 0.90) for all cause mortality, 0.84 (0.78 to 0.91) for CVD mortality, and 0.93 (0.90 to 0.96) for incident CVD events. For CVD events, the association seemed to be stronger among those with prevalent hypertension (P for interaction=0.005).
Conclusions Habitual use of fish oil seems to be associated with a lower risk of all cause and CVD mortality and to provide a marginal benefit against CVD events among the general population.

中文翻译：

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习惯性鱼油补充与心血管疾病的相关性均会导致死亡率：来自大量基于人群的队列研究的证据。

目的评估大量前瞻性队列中习惯性鱼油补充与心血管疾病（CVD）和死亡率的关系。
设计基于人群的前瞻性队列研究。
设置英国生物库。
参与者在2006年至2010年之间，共纳入427678例年龄在40至69岁之间，基线时没有CVD或癌症的男性和女性，并随访至2018年底。
主要接触者所有参与者均回答了有关习惯性使用补充剂的问题，包括鱼油。
主要结果指标均引起死亡率，CVD死亡率和CVD事件。
结果基线时，427 678名参与者中有133 438名（31.2％）报告说习惯性使用鱼油补充剂。习惯性使用鱼油与不使用鱼油的多变量经调整的危险比是：所有原因造成的死亡率分别为0.87（95％置信区间0.83至0.90），CVD死亡率为0.84（0.78至0.91）和事故发生率0.93（0.90至0.96）。 CVD事件。对于CVD事件，在患有高血压的患者中，这种关联似乎更强（相互作用的P = 0.005）。
结论习惯使用鱼油似乎与降低所有原因和CVD死亡率的风险有关，并且在普通人群中对CVD事件提供了微不足道的好处。