New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine.,ACS Medicinal Chemistry Letters

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New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine.
ACS Medicinal Chemistry Letters ( IF 3.5 ) Pub Date : 2020-02-28 , DOI: 10.1021/acsmedchemlett.9b00668
Eleonora Colombo ₁ , Laura Polito ₂ , Michele Biocotino ₁ , Paola Marzullo ₁ , Mariafrancesca Hyeraci ₃ , Lisa Dalla Via ₃ , Daniele Passarella ₁

Affiliation

Betulinic acid is validated as a new self-assembly inducer for the formation of nanoparticles (NPs) in combination with different drugs. The target compounds are characterized by the presence of anticancer drugs acting on tubulin dynamics and of a linker that could be a carbon chain or a triazole-based one. Nanoparticles formed are characterized and their biological activity is evaluated.

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