Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine.,Bioconjugate Chemistry

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Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine.
Bioconjugate Chemistry ( IF 4.0 ) Pub Date : 2020-03-04 , DOI: 10.1021/acs.bioconjchem.0c00029
Victor Choi _{1,

2} , Maneesha A Rajora _{1,

3} , Gang Zheng _{1,

3,

4}

Affiliation

Sonodynamic therapy (SDT) is a promising therapeutic platform for minimally invasive cancer treatment in which acoustically susceptible drug agents, sonosensitizers, are activated by deep-tissue-penetrating low frequency ultrasound. Despite growing research in recent years, the field has yet to clearly elucidate broadly applicable mechanisms by which acoustic cavitation triggers sonosensitizer therapeutic activity, creating difficulties in achieving substantial and translatable therapeutic efficacy. In this review, we will critically analyze the proposed mechanisms underlying SDT and overview how nanomedicines can complement and extend these mechanisms to deliver more efficacious SDT. In doing so, we aim to highlight potential avenues toward viable implementation of SDT as a cancer therapy.

中文翻译：

声音激活药物：声动力疗法背后的机制和纳米医学的作用。

声动力疗法（SDT）是用于微创癌症治疗的有前途的治疗平台，在该平台中，可穿透深层组织的低频超声可激活声敏药物，声敏剂。尽管近年来进行了越来越多的研究，但是该领域尚未清楚阐明声空化触发声敏剂治疗活性的广泛适用的机制，从而在实现实质性和可翻译的治疗功效方面造成了困难。在这篇综述中，我们将批判性地分析提议的SDT机制，并概述纳米药物如何补充和扩展这些机制以提供更有效的SDT。在此过程中，我们旨在强调将SDT切实可行地用于癌症治疗的潜在途径。

更新日期：2020-04-23

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