Where Does the Fluorine Come From? A Review on the Challenges Associated with the Synthesis of Organofluorine Compounds,Organic Process Research & Development

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Where Does the Fluorine Come From? A Review on the Challenges Associated with the Synthesis of Organofluorine Compounds
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2020-03-05 , DOI: 10.1021/acs.oprd.0c00030
Stéphane Caron ₁

Affiliation

Fluorinated organic molecules are increasingly being prepared for a variety of applications, including pharmaceutical products. However, the supply chain to access the necessary raw materials, which originate primarily from calcium fluoride, is often not considered, may be difficult to access at commercial scale, and has become destabilized as more stringent environmental policies are justifiably enforced. This manuscript presents an overview of the preparation and use of simple organofluorinated intermediates and reagents and the challenges associated with them.

中文翻译：

氟从哪里来？综述与有机氟化合物的合成有关的挑战

氟化有机分子正被越来越多地用于包括药物产品在内的各种应用中。但是，通常不考虑获取主要来源于氟化钙的必要原材料的供应链，在商业规模上可能难以获取供应链，并且由于合理实施了更加严格的环境政策，供应链也变得不稳定。该手稿概述了简单的有机氟化中间体和试剂的制备和使用以及与之相关的挑战。

更新日期：2020-04-24

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