A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids,The Journal of Organic Chemistry

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A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2020-03-17 , DOI: 10.1021/acs.joc.0c00312
Shah Nawaz Khan ₁ , Muhammad Kashif Zaman ₁ , Ruining Li ₁ , Zhankui Sun _{1,

2}

Affiliation

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH₄ to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp³ carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.

中文翻译：

羧酸光催化脱羧羟基化反应的一般方法

通过使用分子氧作为绿色氧化剂的可见光诱导的光催化作用，开发了一种用于羧酸脱羧羟基化的通用方法。原位添加NaBH ₄可以减少不稳定的过氧自由基中间体，大大扩大了底物的范围。不同的含sp ³碳的羧酸已成功地用作底物，包括苯乙酸型底物以及脂肪族羧酸。该转化在伯，仲和叔羧酸上可以顺利进行。

更新日期：2020-03-19

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