RNA displays diverse functions in living cells. The presence of various chemical modifications of RNA mediated by enzymes is one of the factors that impart such functional diversity to RNA. Among more than 100 types of RNA modification, N¹-methyladenosine (m¹A) is found mainly in tRNA and rRNA of many living organisms and is known to be deeply implicated in the topology or function of the two classes of RNA. In this commentary article, we would like to deal with the functional significance of m¹A in RNA, and also to describe one methyltransferase installing m¹A in a large subunit rRNA, whose orthologue in Caenorhabditis elegans was discovered recently and was reported in this journal.

中文翻译：

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N 1-甲基腺苷（m1A）RNA修饰：核糖体控制的关键。

RNA在活细胞中显示多种功能。由酶介导的RNA的各种化学修饰的存在是赋予RNA这种功能多样性的因素之一。在100多种类型的RNA修饰中，N ^1-甲基腺苷（m ¹ A）主要存在于许多活生物体的tRNA和rRNA中，并且已知与这两类RNA的拓扑或功能密切相关。在这篇评论文章中，我们要探讨m ¹ A在RNA中的功能意义，并描述一种在大型亚基rRNA中安装m ¹ A的甲基转移酶，该RNA在秀丽隐杆线虫中的直向同源物是最近发现的，并已在此报道。日志。