Morganella morganii, a gram negative, facultative anaerobic bacterium belonging to the Proteeae tribe of the Morganellaceae family, is an unusual opportunistic pathogen mainly responsible for nosocomial and urinary tract infections. While cattle have long been established as a source of a few zoonotic pathogens, no such data has been recorded for M. morganii despite its ubiquitous presence in nature and a number of animal hosts. In this study, draft genomes were produced of three M. morganii isolates from Bangladeshi cattle. The three isolates, named B2, B3 and B5, possessed an average genome size of 3.9 Mp, a GC% of ∼51% and pan and core genomes of 4637 and 3812 genes, respectively. All strains were bearers of the qnrD1 carrying plasmid Col3M and possessed roughly similar virulence profiles and prophage regions. The strains also carried genes that were unique when compared with other publicly available M. morganii genomes. Many of these genes belonged to metabolic pathways associated with adaptation to environmental stresses and were predicted in silico to be borne in genomic islands. The findings of this study expand on the current understanding of M. morganii''s genomic nature and its adaptation in cattle.

中文翻译：

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全基因组测序为从孟加拉国达卡的牛直肠拭子分离的三种摩根氏摩根氏菌菌株提供了基因组学见解。

摩根氏摩根氏菌是革兰氏阴性，兼性厌氧细菌，属于摩根氏菌科的Proteeae部落，是一种罕见的机会病原体，主要负责医院和尿路感染。尽管长期以来已将牛确定为几种人畜共患病原体的来源，但尽管它在自然界和许多动物宿主中无处不在，但尚未记录到摩根摩根氏菌的此类数据。在这项研究中，从孟加拉牛的三种摩氏摩根氏菌分离株产生了基因组草图。这三个分离株分别命名为B2，B3和B5，平均基因组大小为3.9 Mp，GC％为〜51％，泛和核心基因组分别为4637和3812个基因。所有菌株均为携带质粒Col3M的qnrD1的携带者，并具有大致相似的毒力谱和噬菌体区域。与其他可公开获得的摩根摩根氏菌基因组相比，这些菌株还携带独特的基因。这些基因中的许多属于与适应环境压力相关的代谢途径，据预测在计算机上将携带在基因岛中。这项研究的发现扩展了对摩根摩根氏菌的基因组性质及其在牛中的适应性的当前了解。