Gliomas are the most common malignant tumor in the central nervous system and are also one of the leading causes of death in cancer patients. Recently, mounting evidence suggested that both long noncoding RNAs (lncRNAs) and microRNAs play important roles in the proliferation and invasion of cancers, including gliomas. However, the role of lncRNA RP11-626G11.3 in glioma-genesis is still uncovered. Results indicated that lncRNA RP11-626G11.3 was up-regulated in glioma tissues and cell lines, moreover, its overexpression positively correlated with the poor prognosis and advanced pathological stages. Gain and loss of functional experiments demonstrated that lncRNA RP11-626G11.3 promoted the proliferation and invasion of glioma cells in vitro. The knockdown of lncRNA RP11-626G11.3 repressed the tumor growth in vivo. Mechanistically, lncRNA RP11-626G11.3 positively regulated the SP1 expression via competitively sponging with miR-375. Overall, our study shows that lncRNA RP11-626G11.3 promotes glioma progression by sponging miR-375 to regulate SP1 expression, which may provide a novel therapeutic strategy for glioma.

中文翻译：

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长非编码RNA RP11-626G11.3通过miR-375-SP1轴促进神经胶质瘤的进展。


胶质瘤是中枢神经系统最常见的恶性肿瘤，也是癌症患者死亡的主要原因之一。最近，越来越多的证据表明，长链非编码 RNA (lncRNA) 和 microRNA 在癌症（包括神经胶质瘤）的增殖和侵袭中发挥着重要作用。然而，lncRNA RP11-626G11.3 在神经胶质瘤发生中的作用仍不清楚。结果表明，lncRNA RP11-626G11.3在胶质瘤组织和细胞系中表达上调，且其过表达与不良预后和晚期病理阶段呈正相关。功能得失实验表明lncRNA RP11-626G11.3在体外促进胶质瘤细胞的增殖和侵袭。 lncRNA RP11-626G11.3 的敲低抑制了体内肿瘤的生长。从机制上讲，lncRNA RP11-626G11.3 通过与 miR-375 竞争性海绵作用，正向调节 SP1 表达。总的来说，我们的研究表明lncRNA RP11-626G11.3通过海绵miR-375调节SP1表达来促进胶质瘤进展，这可能为胶质瘤提供一种新的治疗策略。