Dr. Thomas Dougherty and his Oncology Foundation of Buffalo were the first to support my (S.O.G.) research into the effects of photodynamic therapy (PDT) on the host immune system. The small grant I was awarded in 2002 launched my career as an independent researcher; at the time, there were few studies on the importance of the immune response on the efficacy of PDT and no studies demonstrating the ability of PDT to enhance antitumor immunity. Over the last decades, the interest in PDT as an enhancer of antitumor immunity and our understanding of the mechanisms by which PDT enhances antitumor immunity have dramatically increased. In this review article, we look back on the studies that laid the foundation for our understanding and provide an update on current advances and therapies that take advantage of PDT enhancement of immunity.

中文翻译：

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光动力疗法和免疫：更新

Thomas Dougherty 博士和他的布法罗肿瘤学基金会是第一个支持我 (SOG) 研究光动力疗法 (PDT) 对宿主免疫系统影响的人。我在 2002 年获得的小额资助开启了我作为独立研究员的职业生涯；当时，关于免疫反应对 PDT 疗效重要性的研究很少，也没有研究证明 PDT 具有增强抗肿瘤免疫的能力。在过去的几十年里，人们对 PDT 作为抗肿瘤免疫增强剂的兴趣以及我们对 PDT 增强抗肿瘤免疫机制的理解急剧增加。在这篇评论文章中，我们回顾了为我们的理解奠定了基础的研究，并提供了利用 PDT 增强免疫力的当前进展和疗法的最新信息。