Acute lymphoblastic leukemia (ALL) is one of the most common hematological malignancies in children. Recent studies suggest the involvement of multiple microRNAs in the tumorigenesis of various leukemias. However, until now, no comprehensive database exists for miRNAs and their cognate target genes involved specifically in ALL. Therefore, we developed 'LeukmiR' a dynamic database comprising in silico predicted microRNAs, and experimentally validated miRNAs along with the target genes they regulate in mouse and human. LeukmiR is a user-friendly platform with search strings for ALL-associated microRNAs, their sequences, description of target genes, their location on the chromosomes and the corresponding deregulated signaling pathways. For the user query, different search modules exist where either quick search can be carried out using any fuzzy term or by providing exact terms in specific modules. All entries for both human and mouse genomes can be retrieved through multiple options such as miRNA ID, their accession number, sequence, target genes, Ensemble-ID or Entrez-ID. User can also access miRNA: mRNA interaction networks in different signaling pathways, the genomic location of the targeted regions such as 3'UTR, 5'UTR and exons with their gene ontology and disease ontology information in both human and mouse systems. Herein, we also report 51 novel microRNAs which are not described earlier for ALL. Thus, LeukmiR database will be a valuable source of information for researchers to understand and investigate miRNAs and their targets with diagnostic and therapeutic potential in ALL. Database URL: http://tdb.ccmb.res.in/LeukmiR/.

中文翻译：

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LeukmiR：急性淋巴细胞白血病中 miRNA 及其靶点的数据库。

急性淋巴细胞白血病（ALL）是儿童最常见的血液恶性肿瘤之一。最近的研究表明多种 microRNA 参与各种白血病的肿瘤发生。然而，到目前为止，还没有专门涉及 ALL 的 miRNA 及其同源靶基因的综合数据库。因此，我们开发了“LeukmiR”动态数据库，其中包含计算机预测的 microRNA，并通过实验验证了 miRNA 及其在小鼠和人类中调节的靶基因。LeukmiR 是一个用户友好的平台，提供所有相关 microRNA 的搜索字符串、它们的序列、目标基因的描述、它们在染色体上的位置以及相应的解除管制的信号通路。对于用户查询，存在不同的搜索模块，其中可以使用任何模糊术语或通过在特定模块中提供精确术语来执行快速搜索。人类和小鼠基因组的所有条目都可以通过多种选项检索，例如 miRNA ID、登录号、序列、目标基因、Ensemble-ID 或 Entrez-ID。用户还可以访问不同信号通路中的 miRNA：mRNA 相互作用网络、目标区域（如 3'UTR、5'UTR 和外显子）的基因组位置及其在人类和小鼠系统中的基因本体和疾病本体信息。在此，我们还报告了 51 种新的 microRNA，这些先前未针对 ALL 进行过描述。因此，LeukmiR 数据库将成为研究人员了解和研究 miRNA 及其在 ALL 中具有诊断和治疗潜力的靶标的宝贵信息来源。数据库网址：http://tdb.ccmb.res.in/LeukmiR/。