Circadian rhythms are prominent in nearly all living organisms and regulated by an endogenous central circadian clock that synchronizes physiological and behavioral processes to the external environment. The circadian clock is driven by the transcriptional-translational negative feedback loop that plays important role in the control of liver function and metabolism. As crucial signaling molecules, bile acids participate in regulating the metabolisms of glucose, lipids, energy, medications, and bile acids themselves. Bile acid synthesis, as well as bile acid-activated key enzymes and nuclear receptors involved in bile acid regulation, also displays distinct circadian variations. Circadian deregulation, such as the consequence of circadian clock disruption, restricted feeding and sleep disruption, can disrupt bile acid homeostasis, resulting in cholestatic and metabolic diseases. This review addresses the circadian rhythms in bile acid synthesis and transport and potential consequences of abnormal disrupted circadian rhythm of bile acid homeostasis.

昼夜节律在几乎所有活生物体中都很突出，并受内生的中央昼夜节律调节，该生物钟使生理和行为过程与外部环境同步。昼夜节律时钟由转录-翻译负反馈回路驱动，该回路在控制肝功能和代谢中起重要作用。作为关键的信号分子，胆汁酸参与调节葡萄糖，脂质，能量，药物和胆汁酸本身的代谢。胆汁酸的合成，以及参与胆汁酸调节的胆汁酸激活关键酶和核受体，也显示出不同的昼夜节律变化。昼夜节律失调（例如昼夜节律紊乱，进食受限和睡眠紊乱的结果）可能会破坏胆汁酸稳态，导致胆汁淤积和代谢疾病。这项审查解决胆汁酸合成和运输中的昼夜节律和胆汁酸稳态的昼夜节律异常破坏的潜在后果。