Psoriasis is a skin inflammatory disorder that affects 3% of the human population. Although several therapies based on the neutralization of proinflammatory cytokines have been used with relative success, additional treatments are required. The in silico analysis of gene expression data of psoriasis lesional skin and an analysis of vitamin B6 metabolites in the sera of psoriasis patients point to altered vitamin B6 metabolism at both local and systemic levels. Functional studies showed that vitamin B6 vitamers reduced skin neutrophil infiltration, oxidative stress and Nfkb activity in two zebrafish models of skin inflammation. Strikingly, inhibition of glycogen phosphorylase L (Pygl) and glucose-6-phosphate dehydrogenase (G6pd), two vitamin B6-dependent enzymes, alleviated oxidative-stress induced inflammation in zebrafish skin inflammation models. Despite the central role of G6pd in antioxidant defenses, the results of the study demonstrate that glycogen stores and G6pd fuel NADPH oxidase to promote skin inflammation, revealing novel targets for the treatment of skin inflammatory disorders.

中文翻译：

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维生素 B6 依赖性酶 PYGL 和 G6PD 为 NADPH 氧化酶提供燃料，以促进皮肤炎症。

银屑病是一种皮肤炎症性疾病，影响 3% 的人口。尽管几种基于中和促炎细胞因子的疗法已取得相对成功，但仍需要额外的治疗。银屑病病变皮肤基因表达数据的计算机分析和银屑病患者血清中维生素 B6 代谢物的分析表明，局部和全身水平的维生素 B6 代谢发生了改变。功能研究表明，维生素 B6 维生素减少了两种斑马鱼皮肤炎症模型中的皮肤中性粒细胞浸润、氧化应激和 Nfkb 活性。引人注目的是，抑制糖原磷酸化酶 L (Pygl) 和葡萄糖-6-磷酸脱氢酶 (G6pd)，这两种维生素 B6 依赖性酶，减轻了斑马鱼皮肤炎症模型中氧化应激诱导的炎症。