In this issue of JEM, Reed-Geaghan et al. (https://doi.org/10.1084/jem.20191374) address the long-standing question about the primary source of myeloid cells located at β-amyloid deposits. Using genetic labeling experiments, the authors identify resident microglia as the only myeloid cells present at β-amyloid deposits.

中文翻译：

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阿尔茨海默病中的小胶质细胞：当地的英雄！


在本期 JEM 中，Reed-Geaghan 等人。 (https://doi.org/10.1084/jem.20191374) 解决了有关位于 β-淀粉样蛋白沉积物的骨髓细胞主要来源的长期问题。通过基因标记实验，作者确定常驻小胶质细胞是存在于 β-淀粉样蛋白沉积物中的唯一骨髓细胞。