We examined the effects of compounds shown to activate aryl hydrocarbon receptor (AhR) signaling on a mouse model of intracerebral hemorrhage (ICH). Daily oral administration of laquinimod (25 mg/kg) or 3,3'-diindolylmethane (250 mg/kg) from 3 h after ICH induction improved motor functions, prevented the decrease of neurons within the hematoma, and attenuated activation of microglia/macrophages and astrocytes in the perihematomal region as well as infiltration of neutrophils into the hematoma. Elevated expression of AhR was detected in microglia and neutrophils, and both drugs inhibited upregulation of interleukin-6 and CXCL1. These results propose AhR as a therapeutic target for ICH.

中文翻译：

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拉喹莫德和 3,3'-二吲哚甲烷可减轻脑出血小鼠模型的神经病理事件和神经功能缺损


我们研究了可激活芳烃受体 (AhR) 信号传导的化合物对小鼠脑出血 (ICH) 模型的影响。 ICH诱导后3小时起每日口服拉喹莫德（25 mg/kg）或3,3'-二吲哚甲烷（250 mg/kg）可改善运动功能，防止血肿内神经元的减少，并减弱小胶质细胞/巨噬细胞的活化血肿周围区域的星形胶质细胞以及中性粒细胞浸润到血肿中。在小胶质细胞和中性粒细胞中检测到 AhR 表达升高，并且两种药物均抑制 IL-6 和 CXCL1 的上调。这些结果表明 AhR 作为 ICH 的治疗靶点。