Four undescribed bioxanthracene derivatives, dongtinganthracenes A-D, along with a previously reported analog, ES-242-3, were obtained from the solid culture broth of the fungus Penicillium sp. DT10, which was isolated from wetland soil obtained from Dongting Lake. Their structures and absolute configurations were elucidated based on extensive NMR analyses, mass spectroscopic analyses, and ECD calculations. Dongtinganthracene A represents the first 7',8'-seco-bioxanthracene produced via oxidation, and dongtinganthracenes A-D show a much higher degree of oxidation in aromatic rings compared with normal naturally occurring bioxanthracene derivatives. Dongtinganthracenes B and D and ES-242-3 exhibit cytotoxic activity, while dongtinganthracene A shows inhibitory activity against LPS-induced NO production.

中文翻译：

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Dongtinganthracenes A-D：来自青霉属的生物黄蒽衍生物。DT10来源于洞庭湖湿地土壤

四种未描述的生物黄蒽衍生物，dongtinganthracenes AD，以及先前报道的类似物 ES-242-3，是从真菌 Penicillium sp. 的固体培养液中获得的。DT10，从洞庭湖湿地土壤中分离得到。基于广泛的核磁共振分析、质谱分析和 ECD 计算阐明了它们的结构和绝对构型。Dongtinganthracene A 代表第一个 7',8'-seco-bioxanthracene 通过氧化产生，与正常的天然生物黄蒽衍生物相比，dongtinganthracenes AD 在芳环中显示出更高的氧化程度。洞庭蒽 B 和 D 以及 ES-242-3 表现出细胞毒活性，而洞庭蒽 A 表现出对 LPS 诱导的 NO 产生的抑制活性。