Inflammatory bowel disease (IBD) characterized by chronic intestinal inflammation and intestinal microbial dysbiosis present a major risk factor in the development of colorectal cancer. Previously, dietary polyphenols from mango (Mangifera indica L.) such as gallotannins and gallic acid have been shown to mitigate intestinal inflammation and carcinogenesis, as well as modulate intestinal microbial composition. To further translate findings from preclinical models, we hypothesized that mango polyphenols possess anti-inflammatory and microbiome-modulatory activities and may improve symptoms of IBD, reduce biomarkers for inflammation and modulate the intestinal microbiome when administered as an adjuvant treatment in combination with conventional medications in patients with mild to moderate IBD. In this study, ten participants received a daily dose of 200-400 g of mango pulp for 8 weeks (NCT02227602). Mango intake significantly improved the primary outcome Simple Clinical Colitis Activity Index (SCCAI) score and decreased the plasma levels of pro-inflammatory cytokines including interleukin-8 (IL-8), growth-regulated oncogene (GRO) and granulocyte macrophage colony-stimulating factor (GM-CSF) by 16.2% (P = .0475), 25.0% (P = .0375) and 28.6% (P = .0485), all factors related to neutrophil-induced inflammation, respectively. Mango intake beneficially altered fecal microbial composition by significantly increasing the abundance of Lactobacillus spp., Lactobacillus plantarum, Lactobacillus reuteri and Lactobacillus lactis, which was accompanied by increased fecal butyric acid production. Therefore, enriching diet with mango fruits or potentially other gallotannin-rich foods seems to be a promising adjuvant therapy combined with conventional medications in the management of IBD via reducing biomarkers of inflammation and modulating the intestinal microbiota.

中文翻译：

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在炎症性肠病患者的一项初步研究中，芒果（Mangifera indica L.）多酚可降低 IL-8、GRO 和 GM-SCF 血浆水平并增加乳酸菌种类

以慢性肠道炎症和肠道微生物生态失调为特征的炎症性肠病 (IBD) 是结直肠癌发展的主要危险因素。此前，来自芒果 (Mangifera indica L.) 的膳食多酚如没食子单宁和没食子酸已被证明可以减轻肠道炎症和致癌作用，并调节肠道微生物组成。为了进一步转化临床前模型的发现，我们假设芒果多酚具有抗炎和微生物组调节活性，当作为辅助治疗与常规药物联合使用时，可以改善 IBD 的症状，减少炎症生物标志物并调节肠道微生物组。轻度至中度 IBD 患者。在这项研究中，10 名参与者每天服用 200-400 克芒果果肉，持续 8 周 (NCT02227602)。芒果摄入量显着改善了主要结果简单临床结肠炎活动指数 (SCCAI) 评分并降低了促炎细胞因子的血浆水平，包括白细胞介素 8 (IL-8)、生长调节癌基因 (GRO) 和粒细胞巨噬细胞集落刺激因子(GM-CSF) 分别增加 16.2% (P = .0475)、25.0% (P = .0375) 和 28.6% (P = .0485)，所有因素都与中性粒细胞诱导的炎症相关。芒果摄入量显着增加了乳酸杆菌属、植物乳杆菌、罗伊氏乳杆菌和乳酸乳杆菌的丰度，从而有益地改变了粪便微生物组成，同时增加了粪便丁酸的产生。所以，