Effective treatment for severe asthma is a significant unmet need. While eosinophilic inflammation caused by type 2 cytokines is responsive to corticosteroid and biologic therapies, many severe asthmatics exhibit corticosteroid‐unresponsive mixed granulocytic inflammation.

中文翻译：

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表皮生长因子受体在 IL-13 介导的皮质类固醇抗性气道炎症中的作用

严重哮喘的有效治疗是一项重大的未满足需求。虽然由 2 型细胞因子引起的嗜酸性粒细胞炎症对皮质类固醇和生物疗法有反应，但许多重度哮喘患者表现出对皮质类固醇无反应的混合性粒细胞炎症。