The role of mitochondria in shaping odor responses in Drosophila melanogaster olfactory sensory neurons.,Cell Calcium

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The role of mitochondria in shaping odor responses in Drosophila melanogaster olfactory sensory neurons.
Cell Calcium ( IF 4.3 ) Pub Date : 2020-02-11 , DOI: 10.1016/j.ceca.2020.102179
Jan Lucke ₁ , Sabine Kaltofen ₁ , Bill S Hansson ₁ , Dieter Wicher ₁

Affiliation

Insects detect volatile chemosignals with olfactory sensory neurons (OSNs) that express olfactory receptors. Among them, the most sensitive receptors are the odorant receptors (ORs), which form cation channels passing also Ca2+. Here, we investigate if and how odor-induced Ca2+ signals in Drosophila melanogaster OSNs are controlled by intracellular Ca2+ stores, especially by mitochondria. Using an open antenna preparation that allows observation and pharmacological manipulation of OSNs we performed Ca2+ imaging to determine the role of Ca2+ influx and efflux pathways in OSN mitochondria. The results indicate that mitochondria participate in shaping the OR responses. The major players of this modulation are the mitochondrial Ca2+ uniporter and the mitochondrial permeability transition pore. Intriguingly, OR-induced Ca2+ signals were only mildly affected by modulating the Ca2+ management of the endoplasmic reticulum.

中文翻译：

线粒体在塑造果蝇嗅觉感觉神经元的气味反应中的作用。

昆虫利用表达嗅觉受体的嗅觉感觉神经元（OSN）检测挥发性化学信号。其中，最敏感的受体是加味剂受体（OR），它们形成也通过Ca2 +的阳离子通道。在这里，我们调查果蝇OSNs中气味诱导的Ca2 +信号是否以及如何受细胞内Ca2 +存储（尤其是线粒体）控制。使用开放式天线准分子，可以观察和药理OSNs，我们进行了Ca2 +成像，以确定Ca2 +内流和外排途径在OSN线粒体中的作用。结果表明线粒体参与塑造OR反应。这种调节的主要参与者是线粒体Ca2 +单向转运蛋白和线粒体通透性过渡孔。有趣的是

更新日期：2020-02-11

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