Developmentally, the uncinate process of the pancreas is derived from the ventral pancreatic anlagen, supplied by the superior mesenteric artery (SMA), and contains pancreatic polypeptide (PP)-rich islets of Langerhans. In contrast, the other parts of the pancreas originate from the dorsal anlagen supplied by the celiac system and contain PP-poor islets. This study was performed to investigate whether morphogenesis of the ventral pancreas anlagen is associated with the pattern of SMA branching. SMA branches to the pancreatic body were dissected in 44 cadavers. The cadavers were divided into two groups: the SMA group in which the SMA gave off branches to the pancreatic body and the General group in which it did not. In the SMA group, the ratio of the diameter of the SMA branch supplying the pancreatic body (SMA branch) to that of the SMA itself was calculated. After dissection was completed, tissues were collected from all pancreatic specimens for HE staining and for immunohistochemistry with PP and insulin antibodies. There were 25 cadavers in the General group and 19 in the SMA group. In 10/19 cadavers from the SMA group, PP-rich islets were confirmed in the pancreatic body. The SMA branch diameter ratio was significantly smaller in the SMA group cadavers with PP-poor islets (n = 9) than in cadavers with PP-rich islets (n = 10) (P < 0.001). These findings suggest a relation between the SMA branching pattern and the distribution of PP cells.

中文翻译：

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SMA分支模式影响腹胰腺胶原蛋白的形态发生。

在发展上，胰​​腺的未融合过程是由腹膜上动脉（SMA）提供的腹侧胰腺胶原蛋白衍生的，并且含有富含胰多肽（PP）的朗格汉斯胰岛。相比之下，胰腺的其他部分则来自腹腔系统供应的背侧胶原蛋白，并且含有贫PP胰岛。进行这项研究以调查腹胰anlagen的形态发生是否与SMA分支模式有关。在44具尸体中解剖了到胰体的SMA分支。尸体分为两组：SMA组，其中SMA向胰体释放分支；普通组，其不向胰体分支。在SMA组中，计算供给胰体的SMA分支的直径（SMA分支）与SMA本身的直径之比。解剖完成后，从所有胰腺标本中收集组织用于HE染色以及与PP和胰岛素抗体的免疫组织化学。一般组有25具尸体，SMA组有19具尸体。在SMA组的10/19尸体中，在胰腺体中证实了富含PP的胰岛。SMA组尸体的PP少的胰岛（n = 9）的SMA分支直径比显着小于富含PP的胰岛的尸体（n = 10）（P <0.001）。这些发现暗示了SMA分支模式与PP细胞分布之间的关系。从所有胰腺标本中收集组织用于HE染色以及与PP和胰岛素抗体的免疫组织化学。一般组有25具尸体，SMA组有19具尸体。在SMA组的10/19尸体中，在胰腺体中证实了富含PP的胰岛。SMA组尸体的PP少的胰岛（n = 9）的SMA分支直径比显着小于富含PP的胰岛的尸体（n = 10）（P <0.001）。这些发现暗示了SMA分支模式与PP细胞分布之间的关系。从所有胰腺标本中收集组织用于HE染色以及与PP和胰岛素抗体的免疫组织化学。一般组有25具尸体，SMA组有19具尸体。在SMA组的10/19尸体中，在胰腺体中证实了富含PP的胰岛。SMA组尸体的PP少的胰岛（n = 9）的SMA分支直径比显着小于富含PP的胰岛的尸体（n = 10）（P <0.001）。这些发现暗示了SMA分支模式与PP细胞分布之间的关系。SMA组尸体的PP少的胰岛（n = 9）的SMA分支直径比显着小于富含PP的胰岛的尸体（n = 10）（P <0.001）。这些发现暗示了SMA分支模式与PP细胞分布之间的关系。SMA组尸体的PP少的胰岛（n = 9）的SMA分支直径比显着小于富含PP的胰岛的尸体（n = 10）（P <0.001）。这些发现暗示了SMA分支模式与PP细胞分布之间的关系。