BACKGROUND Most animals and organs have regenerative capabilities. Whether regeneration is a developmental process or a distinct phenomenon that is independent of development is debatable. METHOD We examined the differences between developing and regenerating salivary glands using duct-ligation models. We performed morphological analyses comparing submandibular gland regeneration and development. To reveal the proliferation processes that occur during salivary gland regeneration and development, we counted the number of Ki67-positive cells over time. In addition, we examined the expression of the following markers: aquaporin 5, smooth muscle actin, cytokeratin 7, and tubulin beta 3. RESULT The proliferation patterns seen during regeneration differed from those observed during development. Different salivary gland marker expression patterns were seen during development and regeneration. CONCLUSION This study showed that regenerating salivary glands do not follow the same growth process as developing salivary glands.

中文翻译：

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唾液腺导管结扎后再生唾液腺与胚胎唾液腺之间的形态学差异。

背景技术大多数动物和器官具有再生能力。再生是一个发展过程还是一个独立于发展的独特现象尚有争议。方法我们使用导管结扎模型检查了唾液腺的发育与再生之间的差异。我们进行了形态学分析，比较下颌下腺的再生和发育。为了揭示唾液腺再生和发育过程中发生的增殖过程，我们计算了一段时间内Ki67阳性细胞的数量。此外，我们检查了以下标志物的表达：水通道蛋白5，平滑肌肌动蛋白，细胞角蛋白7和微管蛋白beta3。结果再生过程中观察到的增殖模式与发育过程中观察到的不同。在发育和再生过程中看到了不同的唾液腺标志物表达模式。结论这项研究表明，唾液腺的再生与发育中的唾液腺的生长过程不同。