AIMS The aim of this paper is to observe the change of aqueous humor levels of placenta growth factor (PlGF) and vascular endothelial growth factor (VEGF) in proliferative diabetic retinopathy (PDR) patients before and one week after intravitreal conbercept injection. METHODS A prospective case series study was conducted in 24 active PDR patients (24 eyes). All the patients had received 0.5 mg of intravitreal conbercept followed by vitrectomy one week later. The aqueous humor was collected before conbercept injection and at the beginning of vitrectomy. RESULTS Before conbercept injection, the aqueous humor median levels of VEGF-A, VEGF-B and PlGF were457.0pg/mL(IQRfrom392.9to860.6pg/mL), 43.6pg/mL(IQRfrom33.6to81.6pg/mL), 37.5pg/mL(IQRfrom25.0to53.6pg/mL), respectively. One week after conbercept injection, the aqueous humor levels of VEGF-A, VEGF-B and PiGF decreased significantly. The aqueous humor VEGF-A levels in PDR patients with fibrovascular membranes were lower than those without them. There was positive correlation between aqueous humor VEGF-B and PiGF levels (P = 0.007). No significant correlation was found between VEGF-A and PiGF levels. No ocular and systemic adverse events were observed. CONCLUSIONS The aqueous humor levels of PlGF was correlated with VEGF-B, and levels of VEGF-A, VEGF-B, and PlGF decreased after intravitreal conbercept injection in active PDR patients.

中文翻译：

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玻璃体内注射conceptcept前后，增生性糖尿病视网膜病变中房水PlGF和VEGF水平的比较。

目的本文旨在观察玻璃体内注射避孕药前后1周的增生性糖尿病视网膜病变（PDR）患者房水中胎盘生长因子（PlGF）和血管内皮生长因子（VEGF）的水平变化。方法对24例活动性PDR患者（24眼）进行了前瞻性病例系列研究。所有患者均于一周后接受0.5 mg玻璃体内conceptcept，随后进行玻璃体切割术。在注射conbercept之前和玻璃体切除术开始时收集房水。结果注射conbercept之前，房水中VEGF-A，VEGF-B和PlGF的中位水平分别为457.0pg / mL（IQR从392.9至860.6pg / mL），43.6pg / mL（IQR从33.6至81.6pg / mL），37.5 pg / mL（IQR从25.0至53.6pg / mL）。注射conbercept后一周，房水中VEGF-A的水平，VEGF-B和PiGF显着降低。有纤维血管膜的PDR患者的房水VEGF-A水平低于无纤维膜的患者。房水VEGF-B与PiGF水平呈正相关（P = 0.007）。在VEGF-A和PiGF水平之间未发现显着相关性。没有观察到眼部和全身不良事件。结论玻璃体注射conbercept对活跃PDR患者的房水水平与VEGF-B相关，VEGF-A，VEGF-B和PlGF水平降低。没有观察到眼部和全身不良事件。结论玻璃体注射conbercept对活跃PDR患者的房水水平与VEGF-B水平相关，而VEGF-A，VEGF-B和PlGF水平下降。没有观察到眼部和全身不良事件。结论玻璃体注射conbercept对活跃PDR患者的房水水平与VEGF-B相关，VEGF-A，VEGF-B和PlGF水平降低。