Individuals living in general indoor environments are exposed to a greater variety of chemical pollutants, albeit at lower concentrations, compared with industrial workers in occupational environments. These pollutants can result in a variety of adverse health effects, including those affecting the respiratory, neurological, reproductive, dermatologic, and cardiovascular systems. In Japan, indoor air quality guidelines have been established for 13 chemicals since 1997, and these developments have continued on the basis of scientific discussions in the Committee on Indoor Air Pollution (CIAP) that was set up by the Ministry of Health, Labour and Welfare. However, the types and concentrations of these pollutants have been observed to be inconsistent over time due to lifestyle changes and the development of novel household products and building materials. Therefore, continuing the monitoring of indoor chemicals and the development of indoor air quality guidelines for substances that pose potential high health risks are essential for the protection of public health. In indoor environments, there are multiple media by which humans come in contact with indoor chemicals and multiple exposure pathways that can affect human health, particularly for semi-volatile organic compounds (SVOCs). This is defined as aggregate exposure. Furthermore, combined exposure to multiple low-level pollutants occurs in indoor environments. In this article, a comprehensive overview of the indoor air quality guidelines in Japan and assessment approaches for developing indoor air quality guidelines is provided. In addition, future issues facing approaches for indoor chemicals, including aggregate exposure to SVOCs and combined exposure to multiple pollutants with common toxicological effects in indoor environments, are discussed.

与职业环境中的工业工人相比，生活在一般室内环境中的个人暴露于更多的化学污染物中，尽管其浓度较低。这些污染物可能导致各种不利的健康影响，包括影响呼吸系统，神经系统，生殖系统，皮肤科和心血管系统的那些污染物。在日本，自1997年以来，已经针对13种化学物质制定了室内空气质量指南，并且在厚生劳动省设立的室内空气污染委员会（CIAP）的科学讨论的基础上，这些发展仍在继续。 。然而，由于生活方式的改变以及新型家用产品和建筑材料的发展，这些污染物的类型和浓度随时间变化不一致。因此，对于可能危害健康的高风险物质，继续监控室内化学物质并制定室内空气质量准则对于保护公众健康至关重要。在室内环境中，人类可以通过多种介质与室内化学物质接触，并且可以通过多种途径影响人体健康，特别是对于半挥发性有机化合物（SVOC）。这被定义为总暴露。此外，在室内环境中会发生多种低水平污染物的综合暴露。在这篇文章中，提供了日本室内空气质量指南的全面概述，并提供了制定室内空气质量指南的评估方法。此外，还讨论了室内化学物质方法面临的未来问题，包括在SVOC中的总体暴露以及在室内环境中共同暴露于具有常见毒理作用的多种污染物。