Immunohistochemical localisation of indoleamine 2,3-dioxygenase was studied in order to better understand the pathophysiology of placenta accreta spectrum. In the decidua staining for indoleamine 2,3-dioxygenase was found in the glandular epithelium with some additional positive cells. Extravillous cytotrophoblast invasion was present in the myometrium which was not covered by the decidual tissue whereas myometrial invasion of cytotrophoblasts was absent where this tissue lay deep to decidua. These results suggest that indoleamine 2,3-dioxygenase expression in the decidua may normally control trophoblast invasion and absence of its expression where decidua is absent may be involved in the pathogenesis of the over-invaded placenta.

中文翻译：

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剖腹产疤痕妊娠中吲哚胺2,3-双加氧酶和滋养细胞的侵袭：对胎盘积聚频谱的发病机理的影响。

为了更好地了解胎盘积聚光谱的病理生理，研究了吲哚胺2，3-二加氧酶的免疫组织化学定位。在蜕膜中，在腺上皮中发现吲哚胺2,3-二加氧酶，还有一些其他阳性细胞。绒毛膜滋养层细胞存在绒毛膜外滋养层，而蜕膜没有被蜕膜组织所覆盖，而子宫肌层滋养细胞的子宫肌层浸润不存在于蜕膜深处。这些结果表明，蜕膜中吲哚胺2，3-二加氧酶的表达通常可以控制滋养细胞的侵袭，而在缺少蜕膜的地方，其表达可能不参与过度侵袭的胎盘的发病机制。