BACKGROUND The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α (TNF-α) gene polymorphisms and coronary artery disease (CAD) susceptibility. METHODS Using appropriate keywords, we identified relevant studies using PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP. Key pertinent sources in the literature were also reviewed, and all articles published through April 2019 were considered for inclusion. Based on eligible studies, we performed a meta-analysis of association between 308G/A, 238G/A, 857C/T, 863C/A and 1031 T/C polymorphisms in TNF-α and risk of CAD. RESULTS We found 25 studies that were consistent with this meta-analysis, including 7697 patients in the CAD group and 9655 control patients. TNF-α 308G/A locus A showed no significant association with CAD susceptibility by the five models in the analysis of the overall population, European, African, South Asian, and North Asian patients. TNF-α 863C/A locus A and 1031 T/C locus C exhibited no significant association with CAD susceptibility. TNF-α 238G/A locus A had no significant association with CAD susceptibility in the overall population. However, TNF-α 238G/A locus A showed significant association with higher CAD susceptibility in the subgroup of Europeans and north Asians. TNF-α 857C/T locus T had no significant association with CAD susceptibility in the analysis of the overall population and Europeans. In the north Asian population, TNF-α 857C/T locus T was associated with lower CAD susceptibility by the heterozygote model. CONCLUSION TNF-α 308G/A, 857C/T, 863C/A, and 1031 T/C has no significant association with CAD susceptibility. TNF-α 238G/A locus A has significant association with CAD susceptibility in Europeans and north Asians, but has no significant association in the overall population. Studies with a larger sample size are required to confirm the association between TNF-α 238G/A and CAD susceptibility.

中文翻译：

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肿瘤坏死因子-α基因多态性与冠状动脉疾病易感性的关联：系统评价和荟萃分析。

背景技术这项研究的目的是回顾相关的病例对照研究，以确定肿瘤坏死因子-α（TNF-α）基因多态性与冠状动脉疾病（CAD）易感性的关系。方法使用适当的关键字，我们使用PubMed，Cochrane，Embase，CNKI，VANFUN和VIP进行了相关研究。还审查了文献中的关键相关来源，并考虑将2019年4月之前发布的所有文章纳入研究。基于合格研究，我们对TNF-α中308G / A，238G / A，857C / T，863C / A和1031 T / C多态性与CAD风险之间的关联进行了荟萃分析。结果我们发现有25项与这项荟萃分析一致的研究，包括CAD组中的7697例患者和9655例对照患者。在分析总体人群，欧洲，非洲，南亚和北亚患者的五个模型中，TNF-α308G / A基因座A与CAD敏感性没有显着相关性。TNF-α863C / A位点A和1031 T / C位点C与CAD敏感性没有显着相关性。TNF-α238G / A基因座A与总人群中CAD易感性无显着相关性。然而，在欧洲人和北亚人的亚组中，TNF-α238G / A基因座A与较高的CAD敏感性显着相关。在总体人群和欧洲人的分析中，TNF-α857C / T基因座T与CAD敏感性没有显着相关性。在北亚人群中，杂合子模型使TNF-α857C / T基因座T与较低的CAD敏感性相关。结论TNF-α308G / A，857C / T，863C / A，1031 T / C与CAD敏感性没有显着关联。在欧洲人和北亚人中，TNF-α238G / A基因座A与CAD易感性有显着关联，但在总人群中无显着关联。需要进行更大样本量的研究以确认TNF-α238G / A与CAD敏感性之间的关联。