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Indoor air chemistry: Terpene reaction products and airway effects.
International Journal of Hygiene and Environmental Health ( IF 6 ) Pub Date : 2020-02-07 , DOI: 10.1016/j.ijheh.2019.113439
Peder Wolkoff 1
Affiliation  

Reactive chemistry is ubiquitous indoors with a wealth of complex oxidation reactions; some of these are initiated by both homogeneous and heterogeneous reaction of ozone with unsaturated organic compounds and subsequent the hydroxyl radical, either in the gas-phase or on reactive surfaces. One major focus has been the reaction of common and abundant terpene-based fragrances in indoor air emitted from many wood-based materials, a variety of consumer products, and citrus fruits and flowers. Inhalation of the terpenes themselves are generally not considered a health concern (both acute and long-term) due to their low indoor air concentrations; however, their gas- and surface reactions with ozone and the hydroxyl radical produce a host of products, both gaseous, i. a. formaldehyde, and ultrafine particles formed by condensation/nucleation processes. These reaction products may be of health concern. Human cell bioassays with key reaction products from ozone-initiated terpene reactions have shown some inflammatory reactions, but results are difficult to interpret for human exposure and risk assessment. Acute effects like sensory irritation in eyes and airways are unlikely or present at very low intensity in real life conditions based on rodent and human exposure studies and known thresholds for sensory irritation in eyes and airways and derived human reference values for airflow limitation and pulmonary irritation. Some fragrances and their ozone-initiated reaction products may possess anti-inflammatory properties. However, long-term effects of the reaction products as ultrafine particles are poorly explored. Material and product surfaces with high ozone deposition velocities may significantly impact the perceived air quality by altered emissions from both homogeneous and heterogeneous surface reactions.



中文翻译:

室内空气化学:萜烯反应产物和气道效应。

反应化学在室内无处不在,具有许多复杂的氧化反应。其中一些是通过臭氧与不饱和有机化合物的均相和异相反应以及随后在气相或反应性表面上的羟基自由基引发的。一个主要关注点是室内空气中常见和丰富的萜烯基香精的反应,这些香精是由许多木质材料,各种消费品以及柑橘类水果和鲜花散发出来的。由于萜烯本身的室内空气浓度低,因此通常不考虑吸入其自身的健康(急性和长期)。然而,用臭氧气体它们和表面反应和羟基自由基产生的产品的宿主,气态,IA甲醛,以及通过缩合/成核过程形成的超细颗粒。这些反应产物可能与健康有关。用臭氧引发的萜烯反应的关键反应产物进行的人体细胞生物测定已显示出一些炎症反应,但难以解释其与人体接触和风险评估的结果。根据啮齿动物和人体暴露研究以及已知的眼和气道感觉刺激阈值以及推导的气流受限和肺刺激性人类参考值,在现实生活中,诸如眼和气道感觉刺激之类的急性效应不太可能或以非常低的强度出现。一些香料及其由臭氧引发的反应产物可能具有抗炎特性。但是,人们对反应产物作为超细颗粒的长期作用的研究很少。

更新日期:2020-02-07
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