Advanced colorectal cancer (CRC) is a significant cause of cancer mortality, with a poor prognosis. Here, we identified a novel prognostic signature for predicting survival of advanced CRC. Advanced CRC data were used (training set: n = 267 and validation set: n = 264). The survival analyses were investigated. The functional analysis of the prognostic signature was examined. In this study, our 15-gene signature was established and was an independent prognostic factor of advanced CRC. Stratification analyses also showed that this signature was still powerful for survival prediction in each stratum of age, gender, stage, and metastasis status. In mechanism, our signature involved in DNA replication, DNA damage, and cell cycle. Therefore, our findings suggested that this 15-gene signature has prognostic and predictive value in advanced CRC, which could be further used in personalized therapy for advanced CRC.

中文翻译：

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开发15基因标记以预测晚期大肠癌的预后。

晚期大肠癌（CRC）是癌症死亡的重要原因，预后较差。在这里，我们确定了一种新的预后标志物，用于预测晚期CRC的生存。使用高级CRC数据（训练集：n = 267和验证集：n = 264）。生存分析进行了调查。检查了预后标志的功能分析。在这项研究中，我们建立了15个基因的标记，并且是晚期CRC的独立预后因素。分层分析还显示，该签名对于年龄，性别，阶段和转移状态的每个阶层的生存预测仍然很有效。在机制上，我们的签名涉及DNA复制，DNA损伤和细胞周期。因此，我们的研究结果表明，这种15个基因的特征在晚期CRC中具有预后和预测价值，