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Immunogenetics in stem cell donor registry work: The DKMS example (Part 2)
International Journal of Immunogenetics ( IF 2.3 ) Pub Date : 2020-02-07 , DOI: 10.1111/iji.12479
Alexander H Schmidt 1, 2, 3 , Jürgen Sauter 1 , Daniel M Baier 1 , Jessica Daiss 1 , Andreas Keller 1 , Anja Klussmeier 2 , Thilo Mengling 1 , Gabi Rall 1 , Tobias Riethmüller 1 , Gerhard Schöfl 2 , Ute V Solloch 1 , Tigran Torosian 4 , David Means 5 , Helen Kelly 6 , Latha Jagannathan 7, 8 , Patrick Paul 7 , Anette S Giani 9 , Sabine Hildebrand 1 , Stephan Schumacher 1 , Jan Markert 1 , Monika Füssel 2 , Jan A Hofmann 1 , Thomas Schäfer 2 , Julia Pingel 1 , Vinzenz Lange 2 , Johannes Schetelig 3, 10
Affiliation  

DKMS is a leading stem cell donor registry with more than 9 million donors. Donor registry activities share many touch points with topics from immunogenetics or population genetics. In this two‐part review article, we deal with these aspects of donor registry work by using the example of DKMS. In the second part of the review, we focus on donor typing of non‐HLA genes, the impact of donor age, gender and CMV serostatus on donation probabilities, the identification of novel HLA, KIR and MIC alleles by high‐throughput donor typing, the activities of the Collaborative Biobank and pharmacogenetics in the donor registry context.

中文翻译:

干细胞捐献者登记工作中的免疫遗传学:DKMS 示例(第 2 部分)

DKMS 是领先的干细胞捐献者登记处,拥有超过 900 万捐献者。捐助者登记活动与免疫遗传学或群体遗传学主题有许多共同点。在这篇由两部分组成的综述文章中,我们通过使用 DKMS 的示例来处理捐赠者登记工作的这些方面。在综述的第二部分,我们重点关注非 HLA 基因的供体分型,供体年龄、性别和 CMV 血清状态对供体概率的影响,通过高通量供体分型鉴定新的 HLA、KIR 和 MIC 等位基因,合作生物库和药物遗传学在捐助者登记方面的活动。
更新日期:2020-02-07
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